The Known Unknowns: A Process for Bringing In Vivo CNS Dosing into Maturity

In recent years in vivo CNS dosing has gone from being a relatively uncommon modality to one that is fairly standard. However, bringing this administration route into maturity requires an understanding of the nuances and unknowns to be resolved. This presentation will discuss several of the challenges and a promising approach to filling in the gaps in our knowledge and creating true best practices that provide reproducible high quality data that will be reliable over time.

Learning objectives:

1. Understand the current gaps in our knowledge of the mechanics of in vivo CNS dosing

2. Design a method to increase out understanding of this modality.

3. Discuss the human factors which will allow us to solve these problems and leverage the expertise of a holistic project group.