Understanding immune activation and evasion in the tumor microenvironment: Why lymphocyte relationships matter

In recent years, significant progress has been made in tissue-based technology, opening up unparalleled opportunities for identifying disease process biomarkers and gaining invaluable insights. Among these advancements, the utilization of tissue phenotyping and multiplex immunofluorescence (mIF) assays has emerged as a transformative approach. Notably, these assays offer a distinct advantage by preserving the architectural characteristics of the tumor microenvironment (TMA) while providing a deeper understanding of the spatial interactions between tumor cells and lymphocytes. As a result, researchers can gain comprehensive and intricate knowledge of the dynamic changes occurring within the TMA. Such advancements hold great promise for enhancing our understanding of diseases and may lead to significant breakthroughs in personalized medicine.

 

Learning Objectives