Sensitivity, Selectivity, and Speed: Solving Analytical Challenges in Endocrinology using LC-MS/MS for Clinical Research

The use of LC-MS/MS technologies in Endocrinology for clinical research is experiencing rapid growth. This is a result of the demonstrated improvements in selectivity, and therefore accuracy, provided by the platform compared to more traditional technologies such as immunoassay. In addition, the ability of LC-MS/MS to monitor large number of analytes in a single method, with improvement in both analytical sensitivity and selectivity, increases the speed at which a sample can be interrogated for biochemical abnormalities. Analytical sensitivity, selectivity and speed are all important aspects of endocrine methodologies which can be augmented by using high sensitivity LC-MS/MS platforms such as the Xevo TQ-S micro and Xevo TQ-XS mass spectrometers. For challenging analyses on these platforms, automation can be employed to simplify the workflow to minimize manual intervention during this process, which helps improve both method robustness and laboratory efficiency.

 

Learning Objectives: