Precision Oncology Unleashed: Challenges and Innovations in ctDNA and Deep Sequencing

ctDNA test, which is an important aspect in liquid biopsy, offers a non-invasive alternative to tissue biopsies for cancer diagnosis and monitoring. Ultra-deep ctDNA sequencing enabling the detection of rare mutations present in a small content of the DNA, which facilitates the growth of molecular pathology and paves the way for improving personalized treatment. Detecting rare ctDNA variants in blood is crucial for cancer diagnosis and treatment monitoring, but faces challenges from technical artifacts and biological factors, especially in low-tumor scenarios. In this webinar, experts from Burning Rock Dx will discuss the latest advancements and challenges in ctDNA sequencing and deep sequencing technologies, highlighting their potential in cancer research and clinical applications.

 

Presentation 1: Deep Learning in Deep Sequencing: Detecting and Monitoring Low-Abundance ctDNA By Bingsi Li, Ph.D.

 

Bingsi Li will showcase how ultra-deep sequencing, combined with deep learning, enhances the accuracy of low-abundance ctDNA detection, offering a powerful tool for liquid biopsy in oncology.

 

 

By Xinru Mao, Ph.D.

 

Xinru Mao will elaborate on the specific performance of ultra-deep sequencing on ctDNA detection and discuss potential clinical applications based on recent research outcomes, paving the way for improving personalized treatment.