Planning for Nutrition for Precision Health, Powered by the All of Us Research Program

Nutrition for Precision Health, powered by the All of Us Research Program (NPH), aims to develop algorithms that predict individual responses to food and dietary patterns. Nutrition plays an integral role in human development and in the prevention and treatment of disease. However, there's no such thing as a perfect, one-size-fits-all diet. The NPH program will build on recent advances in biomedical science including artificial intelligence, microbiome research, as well as the infrastructure and large, diverse participant group of the All of Us Research Program. These advances provide unprecedented opportunities to generate new data to provide insight into precision nutrition. The NPH program will conduct a study nested in the All of Us Research Program to explore how individuals respond to different diets. The NPH study is the first ancillary study to leverage the All of Us infrastructure to answer scientific questions important to participants like understanding more about the role of nutrition in health. High-quality nutrition studies such as the NPH study will help individuals and their health care providers create healthy, precise, and effective diet plans. The objectives of the study are: 1. To examine individual differences observed in response to different diets by studying the interactions between diet, genes, proteins, microbiome, metabolism and other individual contextual factors 2. To use artificial intelligence to develop algorithms to predict individual responses to foods and dietary patterns 3. To validate algorithms for clinical application This presentation will discuss the planning process and next steps for the NPH program.