Next Level of Interactome: Methods for Discovering Novel Protein-Nucleic Acid Interactions from Complex Samples

Mass spectrometry-based proteomics methods are finding increasing use in structural biology research. Beyond simple interaction networks, information about stable protein-protein, protein-ligand or protein-DNA or RNA complexes help to elucidate the biological functions of proteins and nucleic acids in a wider cellular context. New workflow developments and data processing will be discussed as how protein-RNA or DNA interactions can be detected and localized at the single amino acids.