How to Leverage Laser Capture Microdissection Technology for Advanced Oncology Research

 
Understanding genomic variation in the context of cancer is paramount to identifying disease drivers and informing personalized treatment for patients. Tumor heterogeneity presents a challenge in oncology research as conventional methods for studying gene expression look at the tumor as a whole, ignoring the complexities of the many cell types involved in cancer progression. Laser Capture Microdissection (LCM) with the Arcturus Cellect system allows for the isolation of specific tissues and cell types from histology cross sections as well as from live cell cultures. The flexibility of the dual-laser system offers the ability to isolate various sizes of tissue, spanning from large sections of the tumor down to single-cell capture which can then be used for genomic analysis.
 
Learning Objectives:

• Learn how LCM technology works and the benefits of a dual-laser system
• Learn how LCM can be used to uncover genetic variation among different cell types within the tumor microenvironment
• Learn how LCM can be leveraged to attain publication-quality data for oncology research