Exploring the immune-tumor microenvironment using high resolution single-cell spatial transcriptomics

High-resolution spatial transcriptomics stands at the forefront of technological advancements, offering transformative capabilities in the domain of tumor biology research. In this presentation, you will hear about real world examples leveraging this technology to understand the nuances of complex human tumor microenvironment at a spatially resolved single cell level; with a spotlight on DNAM-1 axis immune checkpoint genes currently under evaluation in clinical trials in cancer patients. You will also gain insights into how this technology is successfully used to gain an in-depth look at the DNAM-1 axis in tertiary lymphoid structures. Overall, the findings underscore the immense promise of spatial transcriptomics for deepening the understanding of the tumor microenvironment and to extend the reach of cancer immunotherapies to new patient populations.

 

Learning Objectives