JUN 15, 2023 7:00 AM PDT

Early ctDNA Molecular Response Enhanced Through Integrated Analyses of Cell-Free DNA and Matched White Blood Cells

Sponsored by: Labcorp Oncology
Speakers

Event Date & Time
Date: June 15, 2023
Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST)
Abstract
Liquid biopsies represent a transformation in the management of cancer as they have the potential to detect, characterize, and monitor cancers earlier than can be achieved with conventional diagnostic modalities. Specifically, analyses of circulating tumor DNA have shown promise in capturing tumor burden dynamics during therapeutic intervention, with the potential to allow patients with primary resistance to be rapidly identified and redirected to alternative therapies. However, cell-free DNA-based alterations can be derived from the tumor, germline, or may be associated with clonal hematopoiesis, which can confound non-invasive tumor profiling, molecular response assessment, and clonal evolution analyses through inaccurate variant classification.
 
In this webinar, you’ll learn:
  • How cell-free DNA-based alterations can be accurately classified based on variant origin to inform non-invasive tumor profiling, molecular response assessment, and clonal evolution analyses
  • Results from longitudinal analyses of ctDNA in monitoring therapeutic response during immune checkpoint blockade, demonstrating that ctDNA molecular responses better predict progression-free and overall survival for patients, especially those with radiographically stable disease during therapy.
 
 
Webinars will be available for unlimited on-demand viewing after live event.

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