Mammoth Biosciences is developing next-generation CRISPR platforms to build rapid, point-of-care molecular diagnostics. Our innovative DETECTR technology leverages novel CRISPR proteins whose unique biochemical properties make them well-suited for diagnostic applications . By simply altering the nucleotides in their guide RNA (gRNA), CRISPR proteins can be programmed to find and cut any matching DNA or RNA sequence. These unique CRISPR variants additionally interrogate target nucleic acids with single-nucleotide specificity, and they then function themselves as the catalyst for real-time signal detection. The simplicity of CRISPR has already revolutionized the field of gene editing, and is now enabling a new class of diagnostics. Mammoth Biosciences leverages our diverse CRISPR protein portfolio to build a diagnostic platform that is readily scalable to detect any nucleic acid biomarker of interest.

Learning Objectives:

1. Develop a general understanding of the diversity of CRISPR-Cas systems
2. Understand how CRISPR-Cas systems can be used for diagnostic applications