Postdoctoral Researcher - University of California, San Diego
BIOGRAPHY
JAN 13, 2022 10:25 AM PST
Combined NGS and Optical Genome Mapping Reveal the Complex Structures of Circular Extrachromosomal DNA and other Focal Amplifications in Cancer Genomes
Presented at:
Bionano Genomics 2022 Symposium
Speaker
Abstract
Circular extrachromosomal DNA (ecDNA) is a type of genomic focal amplification frequently found in tumors and is rapidly becoming a foundational frontier in cancer biology. The discovery that genomic focal amplifications can arise by different mechanisms revealed that ecDNA in particular leads to worse patient survival and enhanced tumor evolution. Consequently, there is an urgent need for methods and tools to study ecDNA and related genomic amplifications.
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