Physician-Scientist, Kyushu University
BIOGRAPHY
SEP 28, 2020 5:00 PM PDT
Applying a single-cell GPS to discover novel spatial biomarkers in FFPE tissues
Speakers
-
Aaron Mayer, PhD
Co-Founder and Chief Scientific Officer, Enable MedicineBIOGRAPHY -
Oliver Braubach, Ph.D.
Head of Research Applications at Akoya BiosciencesBIOGRAPHY
Event Date & Time
Date: September 28, 2020, 5:00pm (PDT) / September 29, 2020, 8:00am (HKT), 9:00am (JST)
Abstract
Although there have been dramatic advances in the field of single-cell sequencing, current methods cannot be applied to formalin-fixed paraffin-embedded (FFPE) samples, and the critical spatial context of the tissue is lost. The CODEX system is a simple benchtop platform that enables single-cell phenotyping with spatial information in FFPE tissues and helps researchers understand complex biological mechanisms underlying various diseases. Such high dimensional, unbiased analysis of whole tissue sections can lead to true hypothesis-free discoveries.
In this webinar, the expert speakers will introduce the capabilities of the CODEX system to uncover novel insights from intact tissue sections and focus on graft-versus-host disease (GVHD) of the gut as a case example.
In partnership with Dr. Aaron Mayer at Enable Medicine , Dr. Kohta Miyawaki and his team used a CODEX panel to reveal unique spatial signatures in the gut mucosa that correlate with GVHD prognosis and clinical outcomes in patients that undergo allogeneic hematopoietic stem cell transplantation.
Learning Objectives
- Understand how single-cell spatial analysis can be applied to FFPE tissues
- Understand why high dimensional, whole tissue imaging is important for unbiased spatial phenotyping and biomarker discovery
Webinars will be available for unlimited on-demand viewing after live event.
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.
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