Applying a single-cell GPS to discover novel spatial biomarkers in FFPE tissues

Date:  September 28, 2020,  5:00pm (PDT)  /  September 29, 2020,  8:00am (HKT),  9:00am (JST)

 

Although there have been dramatic advances in the field of single-cell sequencing, current methods cannot be applied to formalin-fixed paraffin-embedded (FFPE) samples, and the critical spatial context of the tissue is lost. The CODEX system is a simple benchtop platform that enables single-cell phenotyping with spatial information in FFPE tissues and helps researchers understand complex biological mechanisms underlying various diseases. Such high dimensional, unbiased analysis of whole tissue sections can lead to true hypothesis-free discoveries.

In this webinar, the expert speakers will introduce the capabilities of the CODEX system to uncover novel insights from intact tissue sections and focus on graft-versus-host disease (GVHD) of the gut as a case example.

 

In partnership with Dr. Aaron Mayer at Enable Medicine , Dr. Kohta Miyawaki and his team used a CODEX panel to reveal unique spatial signatures in the gut mucosa that correlate with GVHD prognosis and clinical outcomes in patients that undergo allogeneic hematopoietic stem cell transplantation.

 

Learning Objectives