Antibody Discovery by Single B Cell Screening on Beacon®

Single B cell screening is a powerful and efficient strategy for generating antigen-specific monoclonal antibodies. Distinguished with fluorescence-activated B cell sorting, the Beacon^® platform is based on plasma cell screening, making it easier to obtain antibody genes.

 

The Beacon^® single-cell optofluidic system combines a unique optoelectro positioning (OEP) technology with novel microfluidic technology. It can be used to accurately select single cells on a chip, perform multiple single-cell assays, and export target cells based on specific results. The Beacon^® optofluidic platform preserves the diversity of B cells, generating high-quality positive hits at an early stage of discovery and avoiding the loss of “good clones”.

 

The webinar will cover the following sections: 1. B cell differentiation and development; 2. Mainstream antibody screening platforms; 3. Beacon^® platform; 4. Case studies using the Beacon^® platform for antibody screening.

 

Learning Objectives