The term viral refers to an infection driven by a virus and examples include COVID-19, AIDS, measles, hepatitis, and smallpox. Viruses contain DNA or RNA and must infect host cells in order to replicate and they can damage the host during this process. Antiviral medications or vaccines can treat viral infections.
Early detection is critical for prompt and effective treatment of acute infectious diseases. For tick-borne diseases (TBD), the lack of accurate early diagnosis can result in delayed treatme...
Analysis of community wastewater has been shown to be an effective method for tracking the prevalence of SARS-COV-2. Our group has developed techniques for sequencing a portion of the SARS-C...
Ribonucleic acid (RNA) has a breathtaking variety of biological functions, which far exceeds its classical role as a carrier of genetic information. The repertoire of this versatile molecule...
We currently do not have effective vaccines or antiviral drugs for most of the viral diseases that afflict humans. Antiviral therapies that enable long-term control over human immunodeficien...
Varicella zoster virus (VZV) causes two clinically distinct forms of disease, varicella and herpes zoster. These forms can each present with multiple manifestations ranging from lesions incl...
Date: September 8, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Implanted biomedical devices comprise a major component of modern medicine and are essential for many clinical applications ranging...
Highly efficacious vaccines against COVD-19 have been generated in a record time, and allowed a great impact in preventing severe disease due to SARS-CoV-2 infection in vaccinated individual...
Microbes are recently recognized as driving the energy and nutrient transformations that fuel Earth’s ecosystems in soils, oceans and humans. Where studied, viruses appear to modulate...
The Human Microbiome Project was conceived almost 15 years ago, as an extension of the Human Genome Project, to explore the diversity of human-associated microorganisms at multiple body site...
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following respiratory virus infections. Strong evidence of a male bias in COVID-...
For centuries, humans have become infected with endemic circulating Coronaviruses (hCoV), typically repeatedly throughout life. To understand how these respiratory infections establish CD4 T...
Self-amplifying RNA replicons are promising candidates for next generation vaccines against human coronaviruses with pandemic potential. Self-amplification of RNAs in host cells generates mo...
Influenza viruses represent a significant burden to human health. In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed. We have...
Innate and adaptive immunity mechanisms provide antiviral protection in mammals. In this talk, I shall present recent findings from my lab and collaborators revealing a distinct form of mamm...
The host antiviral innate immune response involves activation of multiple signaling pathways that result in the production of type I interferons (IFN-I) and inflammatory cytokines, which tog...
Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
Infection with human immunodeficiency virus (HIV)-1 compromises the immune system and causes in about half of the affected individuals neurological and neurocognitive complication categorize...
Nagy is a Professor in the Department of Plant Pathology, University of Kentucky. Dr. Nagy studies the functions of host proteins and lipids in viral RNA replication. The Nagy lab is using a...
The Coronavirus disease 2019 (COVID-19) pandemic poses an unprecedented challenge for public health, which is caused by infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV...
Date: July 07, 2021 Time: 8:00am (PDT), 11:00am (EDT) The DNA damage response is extremely crucial in maintaining genomic integrity. Failure to repair damaged DNA can result in the propagati...
Over 40 tandem repeats undergo expansion events that lead to neurological disease. This number is likely an underestimate as many repeats are difficult to amplify using existing short read s...
Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Despite their debilitating effects and increasing prevalence in society, no cur...
Early detection is critical for prompt and effective treatment of acute infectious diseases. For tick-borne diseases (TBD), the lack of accurate early diagnosis can result in delayed treatme...
Analysis of community wastewater has been shown to be an effective method for tracking the prevalence of SARS-COV-2. Our group has developed techniques for sequencing a portion of the SARS-C...
Ribonucleic acid (RNA) has a breathtaking variety of biological functions, which far exceeds its classical role as a carrier of genetic information. The repertoire of this versatile molecule...
We currently do not have effective vaccines or antiviral drugs for most of the viral diseases that afflict humans. Antiviral therapies that enable long-term control over human immunodeficien...
Varicella zoster virus (VZV) causes two clinically distinct forms of disease, varicella and herpes zoster. These forms can each present with multiple manifestations ranging from lesions incl...
Date: September 8, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Implanted biomedical devices comprise a major component of modern medicine and are essential for many clinical applications ranging...
Highly efficacious vaccines against COVD-19 have been generated in a record time, and allowed a great impact in preventing severe disease due to SARS-CoV-2 infection in vaccinated individual...
Microbes are recently recognized as driving the energy and nutrient transformations that fuel Earth’s ecosystems in soils, oceans and humans. Where studied, viruses appear to modulate...
The Human Microbiome Project was conceived almost 15 years ago, as an extension of the Human Genome Project, to explore the diversity of human-associated microorganisms at multiple body site...
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following respiratory virus infections. Strong evidence of a male bias in COVID-...
For centuries, humans have become infected with endemic circulating Coronaviruses (hCoV), typically repeatedly throughout life. To understand how these respiratory infections establish CD4 T...
Self-amplifying RNA replicons are promising candidates for next generation vaccines against human coronaviruses with pandemic potential. Self-amplification of RNAs in host cells generates mo...
Influenza viruses represent a significant burden to human health. In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed. We have...
Innate and adaptive immunity mechanisms provide antiviral protection in mammals. In this talk, I shall present recent findings from my lab and collaborators revealing a distinct form of mamm...
The host antiviral innate immune response involves activation of multiple signaling pathways that result in the production of type I interferons (IFN-I) and inflammatory cytokines, which tog...
Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
Flaviviruses are pathogens of global public health concern. They include dengue virus (DENV), West Nile virus (WNV), and zika virus (ZIKV). There are no approved US Food and Drug Administrat...
Infection with human immunodeficiency virus (HIV)-1 compromises the immune system and causes in about half of the affected individuals neurological and neurocognitive complication categorize...
Nagy is a Professor in the Department of Plant Pathology, University of Kentucky. Dr. Nagy studies the functions of host proteins and lipids in viral RNA replication. The Nagy lab is using a...
The Coronavirus disease 2019 (COVID-19) pandemic poses an unprecedented challenge for public health, which is caused by infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV...
Date: July 07, 2021 Time: 8:00am (PDT), 11:00am (EDT) The DNA damage response is extremely crucial in maintaining genomic integrity. Failure to repair damaged DNA can result in the propagati...
Over 40 tandem repeats undergo expansion events that lead to neurological disease. This number is likely an underestimate as many repeats are difficult to amplify using existing short read s...
Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Despite their debilitating effects and increasing prevalence in society, no cur...
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