Systems Biology: Systems biology is the computational and mathematical modeling of complex biological systems. It is a biology-based interdisciplinary field of study that focuses on complex interactions within biological systems, using a holistic approach to biological research.
Finding effective treatments for cancer is fundamentally a high-dimensional probabilistic planning, search, and optimization problem, characterized by thousands of molecular subty...
Crohn’s disease and ulcerative colitis also known as inflammatory bowel diseases or IBD, are characterized by chronic, recurrent inflammation of the gastrointestinal tract, which result...
Rare disease affects 30 million people in the United States, with nearly 50% of cases affecting children. Because nearly 80% of rare diseases are genetic, advancements in genomic testing are...
Regulation of precision medicine is rapidly evolving. The pre-existing regulatory framework did not contemplate many of the products and technologies which are becoming available with p...
Recent advancements in the precision medicine field have presented a great promise to provide innovative solutions to pharmaceutical and healthcare industry to help transform medicine. By fin...
With nearly 9 million covered lives serviced through over 150 medical centers, the VA is one of the largest, unified Healthcare System within the United States. Embedded within this system is...
The therapeutic applications of medical cannabis and cannabinoid drugs is controversial, however the number of medical conditions in which cannabinoids and cannabis have shown promise as ther...
With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, there is an urgent need for clinical support tools that aid clinicians in their decision making. To this...
When the human genome was sequenced almost 15 years ago, it was a milestone for the understanding of an individual’s genome. However to fully understand a disease, millions of ind...
Precision medicine based on molecular profiling is moving from the realm of clinical utility studies towards standard of care. There remain, however, significant technological and implementat...
Precision medicine and next-generation sequencing – Two terms characterized by a highly dynamic nature, strong innovations and a bright future. Both merged together will exert a decisiv...
I will discuss three novel technologies that our laboratory has developed in recent years. In the first part of the talk, I will describe our work on engineering variants of the RNA-guided en...
The pharmaceutical industry’s productivity crisis is well known with >90% of drug candidates failing in clinical testing, primarily due to unexpected toxicity or lack of efficacy. &n...
DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
Getting started with an unfamiliar life science research application or a new product can always present challenges. LabCoat Live SmartStart Training is a professional interactive education e...
Studying the molecular machinery of cells from atomic detail to the cellular context and beyond is a great challenge for cell biology. It is hugely important to zoom into the atom-by-atom arr...
Reliable expression of recombinant proteins in human or CHO cells is essential for many aspects of biomedical research and drug development but is often hampered by low expression yields that...
G protein-coupled receptors (GPCRs) regulate virtually all known physiological processes and are a premier class of drug targets. However, a detailed mechanistic understanding of their...
The Baculovirus Expression Vector System (BEVS) is one of the major platforms for recombinant protein production. Unlike mammalian expression systems that have long since transitioned to seru...
The ExpiCHO and Expi293 transient expression systems offer all-in-one solutions for generating high-titer recombinant proteins for a broad range of research applications including candidate d...
Many research laboratories use the ExpiCHO Expression System to transiently produce candidate biomolecules for biologics development. However, after the lead candidate is found, a stable cell...
Finding effective treatments for cancer is fundamentally a high-dimensional probabilistic planning, search, and optimization problem, characterized by thousands of molecular subty...
Crohn’s disease and ulcerative colitis also known as inflammatory bowel diseases or IBD, are characterized by chronic, recurrent inflammation of the gastrointestinal tract, which result...
Rare disease affects 30 million people in the United States, with nearly 50% of cases affecting children. Because nearly 80% of rare diseases are genetic, advancements in genomic testing are...
Regulation of precision medicine is rapidly evolving. The pre-existing regulatory framework did not contemplate many of the products and technologies which are becoming available with p...
Recent advancements in the precision medicine field have presented a great promise to provide innovative solutions to pharmaceutical and healthcare industry to help transform medicine. By fin...
With nearly 9 million covered lives serviced through over 150 medical centers, the VA is one of the largest, unified Healthcare System within the United States. Embedded within this system is...
The therapeutic applications of medical cannabis and cannabinoid drugs is controversial, however the number of medical conditions in which cannabinoids and cannabis have shown promise as ther...
With prospective clinical sequencing of tumors emerging as a mainstay in cancer care, there is an urgent need for clinical support tools that aid clinicians in their decision making. To this...
When the human genome was sequenced almost 15 years ago, it was a milestone for the understanding of an individual’s genome. However to fully understand a disease, millions of ind...
Precision medicine based on molecular profiling is moving from the realm of clinical utility studies towards standard of care. There remain, however, significant technological and implementat...
Precision medicine and next-generation sequencing – Two terms characterized by a highly dynamic nature, strong innovations and a bright future. Both merged together will exert a decisiv...
I will discuss three novel technologies that our laboratory has developed in recent years. In the first part of the talk, I will describe our work on engineering variants of the RNA-guided en...
The pharmaceutical industry’s productivity crisis is well known with >90% of drug candidates failing in clinical testing, primarily due to unexpected toxicity or lack of efficacy. &n...
DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
Getting started with an unfamiliar life science research application or a new product can always present challenges. LabCoat Live SmartStart Training is a professional interactive education e...
Studying the molecular machinery of cells from atomic detail to the cellular context and beyond is a great challenge for cell biology. It is hugely important to zoom into the atom-by-atom arr...
Reliable expression of recombinant proteins in human or CHO cells is essential for many aspects of biomedical research and drug development but is often hampered by low expression yields that...
G protein-coupled receptors (GPCRs) regulate virtually all known physiological processes and are a premier class of drug targets. However, a detailed mechanistic understanding of their...
The Baculovirus Expression Vector System (BEVS) is one of the major platforms for recombinant protein production. Unlike mammalian expression systems that have long since transitioned to seru...
The ExpiCHO and Expi293 transient expression systems offer all-in-one solutions for generating high-titer recombinant proteins for a broad range of research applications including candidate d...
Many research laboratories use the ExpiCHO Expression System to transiently produce candidate biomolecules for biologics development. However, after the lead candidate is found, a stable cell...
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