Regeneration: is the process by which lost or damaged tissues, organs or limbs are re-formed from the remaining tissue. During regeneration, adult stem cells and/or progenitor cells differentiate to replace the missing tissue, although in some instances differentiated cells can also participate in the regeneration by proliferation or transdifferentiation.
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Recent advances in single-cell RNA sequencing are producing exciting new insights into cell diversity within different tissues and cancers. Listen in to hear Dr Gonçalo Castelo-B...
Inherited retinal degenerative disorders such as retinitis pigmentosa are characterized by death of the light sensing photoreceptive neurons of the outer retina. Like the rest of the CNS, the...
My research program focuses on building the technology to generate diverse human cell-types for application in regenerative medicine and drug toxicology testing. While embryonic stem cells (E...
In healthy liver, quiescent hepatic stellate cells (HSCs) participate in the homeostasis of extracellular matrix and store vitamin A. After injury, HSCs activate and participate in the wound-...
Years of significant effort can go into generating key proof of concept data to support moving bench research to clinical development.Yet, much work remains in order to transition from POC to...