Breast cancers can be identified by specific molecular subtypes based on gene expression within the cancer cells. The most common genes investigated for molecular subtyping of breast cancer are the estrogen receptor (ER) and progesterone receptor (PR), which are together classified as hormone receptor (HR), and human epidermal growth factor receptor (HER2), a protein that helps breast cancers grow. There are four major subtypes HR+/Her2- , HR-/HER2- (also known as triple negative breast cancer), HR+/HER2+, and HR-/HER2+.