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Long-Read Sequencing
Long-Read Sequencing, also known as third-generation sequencing, is a class of DNA sequencing methods which are currently under active development. In contrast to other existing methods of DNA sequencing the process of long-read sequencing does not require breaking long strands of DNA, but simply reading the nucleotide sequences at a molecule level.
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SEP 30, 2020 | 12:00 AM
An extensively debated concern about CRISPR-Cas9 genome editing is that unspecific guide RNA (gRNA) binding may induce off-target mutations. However, accurate prediction of CRISPR-Cas9 off-t...SEP 10, 2020 | 12:00 AM
Focusing on the urgent clinical problem of increasing carbapenem resistance in Enterobacteriaceae we have been evaluating detection methods in clinical microbiology and molecular transmissio...SEP 10, 2020 | 12:00 AM
The microbiome has emerged as a major contributor to human health and disease. Numerous sources implicate shifts in the gut microbiome as potentially pathologic for a variety of autoimmune d...SEP 10, 2020 | 12:00 AM
The transfer of antimicrobial resistance genes (ARG) to pathogenic microbes is a major concern in modern medicine. Antibiotic therapies are often rendered ineffective by horizontal acquisiti...SEP 09, 2020 | 12:00 AM
The regions of our genome responsible for encoding the genes that regulate our immune response are some of the most complex and polymorphic known. This complexity encompasses multiple types...SEP 09, 2020 | 12:00 AM
Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). The region has certain properties such as single nucleotide variation, structural variation,...APR 24, 2020 | 8:00 AM
DATE: April 24, 2020 TIME: 8:00am PT, 11:00am ET, 5:00pm CET...APR 23, 2020 | 7:30 AM
The development of automated DNA sequencers using fluorescent di-deoxy nucleotide sequencing and capillary electrophoresis made it possible to generate the first draft sequences of the human...APR 22, 2020 | 12:00 AM
Complex genomes, including the human genome, contain ‘dark’ regions that standard short-read sequencing technologies do not adequately resolve—overlooking many variants tha...APR 21, 2020 | 12:00 PM
Within the clinical arena, the oncology community has led the way in the early adoption of next generation sequencing. NGS is in widespread use in clinical cancer research and is now beginni...APR 21, 2020 | 10:30 AM
The introduction of PacBio HiFi sequence reads, which are both long (up to 25 kb currently) and accurate (>99%) at the individual single-molecule sequence read level, has allowed for adva...Speaker: Jonas Korlach, PhDAPR 21, 2020 | 5:30 AM
Long-read DNA sequencing technologies such as the Pacific Biosciences (PacBio) and Oxford Nanopore (ONT) platforms, have demonstrated enhanced detection of genomic variation, including Singl...APR 21, 2020 | 12:00 AM
Single cell RNA sequencing (scRNA-seq) emerged to characterize gene expression differences between individual cells, allowing a higher resolution look at mRNA abundance than bulk RNA- seq. H...APR 21, 2020 | 12:00 AM
Learning Objectives: 1. Learn why the complexity and repetitive structure of the human genome makes it impossible to detect all structural variants using short-read sequencing 2. Learn how h...APR 21, 2020 | 12:00 AM
Structural variation within plant genomes has fueled domestication and selection of traits critical for modern breeding of crop plants. Nevertheless, dissecting the diversity of structural v...APR 02, 2020 | 8:00 AM
DATE: April 2, 2020 TIME: 8:00am PT, 11:00am ET Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression. We recently identified a hepatocellular carcinoma (HCC)...DEC 04, 2019 | 7:00 AM
DATE: December 4, 2019TIME: 7:00am PST, 10:00am EST, 4:00pm CET Do you know how it feels when you just quickly want to redo an experiment that your colleague did, or an experim...OCT 30, 2019 | 7:00 AM
DATE: October 30, 2019TIME: 7:00am PDTJoin us for a webinar to learn how to apply single cell methods to study cancer. Dr. William Greenleaf, Associate Professor from Stanford Universit...OCT 15, 2019 | 10:00 AM
DATE: October 15, 2019TIME: 10:00am PDTAdvances in Next-Generation Sequencing technologies as well as bioinformatic tools have advanced our ability to research and explore both human...OCT 10, 2019 | 10:30 AM
Accumulation of structural variations (SVs) across the genome is a known trigger factor for oncogenesis. Structural mutations have been clearly implicated in a number of cancers, most notably...Speaker: Sven Bocklandt, PhDSEP 11, 2019 | 1:30 PM
Background: The vast majority of all genes are contained within the genomes of the prokaryotes, including the eubacteria and the archaea. These largely single-cellular domains of life thus...Speaker: Garth Ehrlich, PhD, FAAASAUG 14, 2019 | 8:00 AM
DATE: August 14, 2019TIME: 8:00am PDT Infectious disease surveillance and monitoring is critical in settings where disease outbreaks and antibiotic resistance can dramatically im...JUN 20, 2019 | 1:30 PM
The practice of precision medicine utilizes advanced diagnostic tools to identify specific groups of patients on the basis of particular molecular characteristics, and guide their treatment w...Speaker: David Hout, PhD , Benjamin Chaffey, PhDJUN 20, 2019 | 10:30 AM
Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...Speaker: Beate Litzenburger, Ph.D. , Raed Samara, PhD
SEP 30, 2020 | 12:00 AM
An extensively debated concern about CRISPR-Cas9 genome editing is that unspecific guide RNA (gRNA) binding may induce off-target mutations. However, accurate prediction of CRISPR-Cas9 off-t...
SEP 10, 2020 | 12:00 AM
Focusing on the urgent clinical problem of increasing carbapenem resistance in Enterobacteriaceae we have been evaluating detection methods in clinical microbiology and molecular transmissio...
SEP 10, 2020 | 12:00 AM
The microbiome has emerged as a major contributor to human health and disease. Numerous sources implicate shifts in the gut microbiome as potentially pathologic for a variety of autoimmune d...
SEP 10, 2020 | 12:00 AM
The transfer of antimicrobial resistance genes (ARG) to pathogenic microbes is a major concern in modern medicine. Antibiotic therapies are often rendered ineffective by horizontal acquisiti...
SEP 09, 2020 | 12:00 AM
The regions of our genome responsible for encoding the genes that regulate our immune response are some of the most complex and polymorphic known. This complexity encompasses multiple types...
SEP 09, 2020 | 12:00 AM
Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). The region has certain properties such as single nucleotide variation, structural variation,...
APR 24, 2020 | 8:00 AM
DATE: April 24, 2020 TIME: 8:00am PT, 11:00am ET, 5:00pm CET...
APR 23, 2020 | 7:30 AM
The development of automated DNA sequencers using fluorescent di-deoxy nucleotide sequencing and capillary electrophoresis made it possible to generate the first draft sequences of the human...
APR 22, 2020 | 12:00 AM
Complex genomes, including the human genome, contain ‘dark’ regions that standard short-read sequencing technologies do not adequately resolve—overlooking many variants tha...
APR 21, 2020 | 12:00 PM
Within the clinical arena, the oncology community has led the way in the early adoption of next generation sequencing. NGS is in widespread use in clinical cancer research and is now beginni...
APR 21, 2020 | 10:30 AM
The introduction of PacBio HiFi sequence reads, which are both long (up to 25 kb currently) and accurate (>99%) at the individual single-molecule sequence read level, has allowed for adva...
Speaker:
Jonas Korlach, PhD
APR 21, 2020 | 5:30 AM
Long-read DNA sequencing technologies such as the Pacific Biosciences (PacBio) and Oxford Nanopore (ONT) platforms, have demonstrated enhanced detection of genomic variation, including Singl...
APR 21, 2020 | 12:00 AM
Single cell RNA sequencing (scRNA-seq) emerged to characterize gene expression differences between individual cells, allowing a higher resolution look at mRNA abundance than bulk RNA- seq. H...
APR 21, 2020 | 12:00 AM
Learning Objectives: 1. Learn why the complexity and repetitive structure of the human genome makes it impossible to detect all structural variants using short-read sequencing 2. Learn how h...
APR 21, 2020 | 12:00 AM
Structural variation within plant genomes has fueled domestication and selection of traits critical for modern breeding of crop plants. Nevertheless, dissecting the diversity of structural v...
APR 02, 2020 | 8:00 AM
DATE: April 2, 2020 TIME: 8:00am PT, 11:00am ET Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression. We recently identified a hepatocellular carcinoma (HCC)...
DEC 04, 2019 | 7:00 AM
DATE: December 4, 2019TIME: 7:00am PST, 10:00am EST, 4:00pm CET Do you know how it feels when you just quickly want to redo an experiment that your colleague did, or an experim...
OCT 30, 2019 | 7:00 AM
DATE: October 30, 2019TIME: 7:00am PDTJoin us for a webinar to learn how to apply single cell methods to study cancer. Dr. William Greenleaf, Associate Professor from Stanford Universit...
OCT 15, 2019 | 10:00 AM
DATE: October 15, 2019TIME: 10:00am PDTAdvances in Next-Generation Sequencing technologies as well as bioinformatic tools have advanced our ability to research and explore both human...
OCT 10, 2019 | 10:30 AM
Accumulation of structural variations (SVs) across the genome is a known trigger factor for oncogenesis. Structural mutations have been clearly implicated in a number of cancers, most notably...
Speaker:
Sven Bocklandt, PhD
SEP 11, 2019 | 1:30 PM
Background: The vast majority of all genes are contained within the genomes of the prokaryotes, including the eubacteria and the archaea. These largely single-cellular domains of life thus...
Speaker:
Garth Ehrlich, PhD, FAAAS
AUG 14, 2019 | 8:00 AM
DATE: August 14, 2019TIME: 8:00am PDT Infectious disease surveillance and monitoring is critical in settings where disease outbreaks and antibiotic resistance can dramatically im...
JUN 20, 2019 | 1:30 PM
The practice of precision medicine utilizes advanced diagnostic tools to identify specific groups of patients on the basis of particular molecular characteristics, and guide their treatment w...
Speaker:
David Hout, PhD
, Benjamin Chaffey, PhD
JUN 20, 2019 | 10:30 AM
Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...
Speaker:
Beate Litzenburger, Ph.D.
, Raed Samara, PhD