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In Vitro
In Vitro: refers to a medical test or experiment/procedure that is conducted in a laboratory within the confines of a test tube or laboratory dish. This is not to be confused with the term in vivo, which is a medical test or procedure that is performed on or in a living organism.
JAN 01, 2020 | 6:00 AM
The liver plays a critical role in the metabolism and clearance of more than 70% of marketed drugs. Furthermore, toxicity to the liver is a major reason for preclinical and clinical drug fai...
JAN 01, 2020 | 6:00 AM
“The poor translatability of early-stage preclinical models is a major setback in oncology drug development. Immortalized cell lines, that are extensively used in drug screens, undergo...
JAN 01, 2020 | 6:00 AM
Misfolded and accumulated neurodegenerative disease associated proteins (NDAPs, such as tau and alpha-synuclein) represent the major pathological hallmark in Alzheimer’s and Parkinson&...
JAN 01, 2020 | 6:00 AM
Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
JAN 01, 2020 | 6:00 AM
The use of primary cells in vitro is compromised by the limited quantity of cells that can be isolated from one donor, a lack of or very restricted proliferation capacity (e.g. hepatocytes)...
JAN 01, 2020 | 6:00 AM
The aim of the lecture is to give an insight into the use of 3D liver micro tissues (3D liMTs) in drug discovery and translational safety. In translational toxicology, 3D LiMTs have a high i...
JAN 01, 2020 | 6:00 AM
Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
