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    Human Biology

    Human biology is the branch of biology that focuses on human beings and human populations; it encompasses all aspects of the human organism including genetics, ecology, anatomy and physiology, anthropology, and nutrition, among others. Human biology is related to other fields of biology such as medicine, primate biology, and biological anthropology.

    Webinars

    • FEB 07, 2017 | 10:00 AM
      WEBINAR: Beyond 100,000: Insights & Lessons from Large-Scale Sequencing in the Cloud
      WEBINAR: Beyond 100,000: Insights & Lessons from Large-Scale Sequencing...
      DATE: February 7, 2017TIME: 10:00am PT, 1:00pm ETIn this webinar, Jeffrey G. Reid, PhD, Executive Director and Head of Genome Informatics at Regeneron Pharmaceuticals, will sh...
      Speaker: Jeffrey Reid, PhD
      Sponsored By: DNAnexus
      13 3
      JAN 31, 2017 | 9:00 AM
      WEBINAR: Networks of exchanging antibiotic resistance across human commensal, environmental, and pathogenic bacteria
      WEBINAR: Networks of exchanging antibiotic resistance across human...
      DATE: January 31, 2017TIME: 9:00AM PT, 12:00PM ET Gautam Dantas - While the most acute effects of increasing antibiotic resistance in pathogens are observed in clinical se...
      Speaker: Gautam Dantas, PhD , Shuiquan Tang, PhD
      Sponsored By: Zymo Research, Zymo Research
      18 14
      JAN 27, 2017 | 4:00 AM
      WEBINAR: Highly Multiplexed Single Cell Analysis Of Tumor Heterogeneity Through Time and Space by Mass Cytometry
      WEBINAR: Highly Multiplexed Single Cell Analysis Of Tumor Heterogeneity...
      DATE: January 27, 2017TIME: 4:00am PT, 7:00am ET, 1:00pm CETThe study of the tumor ecosystem and its cell-to-cell communications is essential to enable an understanding of tumor biology...
      Speaker: Bernd Bodenmiller, PhD , Randall Wetzel, PhD
      Sponsored By: Cell Signaling Technology, Cell Signaling Technology
      16
      NOV 17, 2016 | 3:00 AM
      Genetic variability of ps-iPSC and related blood and fibroblasts - somatic mutations
      Genetic variability of ps-iPSC and related blood and fibroblasts...
      The generation of induced pluripotent stem cells (iPSCs) from adult easily accessible somatic tissues was introduced ten years ago. This technology has revolutionized our opportunities to stu...
      Speaker: KEYNOTE: Silke Rickert-Sperling, PhD
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      8 1
      NOV 16, 2016 | 4:00 PM
      Evolving your media system for modern stem cell applications
      Evolving your media system for modern stem cell applications
      Culture systems for pluripotent stem cell (PSC) expansion enable generation of a nearly unlimited pool of cells for downstream differentiation, disease modeling, drug discovery, and therapeut...
      Speaker: Rhonda Newman, PhD
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      4
      NOV 16, 2016 | 8:00 AM
      The important role of lncRNAs in breast cancer
      The important role of lncRNAs in breast cancer
      DATE:  November 16, 2016 TIME:  8:00am PT, 11:00am ET  Breast cancer is the most commonly diagnosed cancer in women and is the second leading cause of cancer death among wo...
      Speaker: Rebecca DeVaux, PhD , Alfredo Hidalgo-Miranda, PhD
      Sponsored By: Affymetrix, Affymetrix
      8
      NOV 10, 2016 | 7:30 AM
      Does your protein analysis toolbox need a refresh?
      Does your protein analysis toolbox need a refresh?
      DATE:  November 10, 2016 TIME:  7:30am PT, 10:30am ET  Does your protein analysis toolbox need a refresh? Do you have a firm grasp on the tools available and when each migh...
      Speaker: Rich Jones, PhD
      Presented at: Beckman Coulter Life Sciences Virtual Trade Show
      Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
      4
      NOV 03, 2016 | 6:00 AM
      Automation and core-laboratory: experience of a large European academic hospital
      Automation and core-laboratory: experience of a large European...
      Core or central laboratory are facing several challenges. First, the management and operations of a successful modern laboratory is a real complex exercise, with multiple pre- and post-analyt...
      Speaker: Damien Gruson, PhD
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2016
      2
      NOV 02, 2016 | 9:00 AM
      Vitamin D supplementation in Pregnant Women: Effects on Preeclampsia and Asthma in the Offspring
      Vitamin D supplementation in Pregnant Women: Effects on Preeclampsia...
      Vitamin D insufficiency and deficiency are prevalent worldwide, and pregnant women and infants are at highest risk for having deficiency and related consequences. Epidemiologic studies have s...
      Speaker: Augusto Litonjua, MD, PhD , Scott Weiss, MD, MS
      Presented at: Clinical Diagnostics & Research Virtual Event Series 2016
      4
      OCT 06, 2016 | 10:30 AM
      Decoding human tumors and healthy tissue with mass cytometry
      Decoding human tumors and healthy tissue with mass cytometry
      New generations of treatments successfully target cancer cell signaling and modulate anti-cancer immunity to improve outcomes for advanced-stage malignancies. Such clinical responses are gove...
      Speaker: Jonathan Irish, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
      0
      OCT 06, 2016 | 7:30 AM
      Keynote Speaker: Reference Component Analysis of Single Cell Transcriptomes Reveals Cellular Heterogeneity in Colorectal Cancer
      Keynote Speaker: Reference Component Analysis of Single Cell Transcriptomes...
      Intra-tumor heterogeneity is a major obstacle to cancer treatment. Existing single-cell studies of intra-tumor heterogeneity have largely focused on DNA mutations; functional heterogeneity is...
      Speaker: Shyam Prabhakar, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
      2
      OCT 05, 2016 | 6:00 AM
      Melanoma - View from the Frontlines of Immunotherapy and Precision Medicine
      Melanoma - View from the Frontlines of Immunotherapy and Precision...
      Melanoma arises in the pigment producing cells (melanocytes) and is the deadliest of the skin cancers. It accounts for nearly 200,000 new cases of cancer each year worldwide and in the U.S. o...
      Speaker: Louise Perkins, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
      2
      OCT 04, 2016 | 8:00 AM
      Overcoming the Clinical Sample Bottleneck for Expression Studies
      Overcoming the Clinical Sample Bottleneck for Expression Studies
      DATE:  October 4, 2016 TIME:  8:00am PT, 11:00am ET Extracting robust expression data from clinical samples represents a unique opportunity to find actionable biomarkers. But it...
      Speaker: Mark Manary, MD , Sean Diehl, PhD
      Sponsored By: Affymetrix, Affymetrix
      4
      SEP 20, 2016 | 8:00 AM
      Use of Surface Plasmon Resonance for Probing Cell-Matrix Interactions
      Use of Surface Plasmon Resonance for Probing Cell-Matrix Interactions
      DATE: September 20, 2016 TIME: 8:00am PST, 11:00 EST Studies of cell-substrate interactions are important for an array of biotechnology applications.  The nature of specific, recepto...
      Speaker: Michael Hill
      Sponsored By: Ametek, Ametek , Ametek
      7 5
      SEP 08, 2016 | 10:30 AM
      The Serious Science of Schmutz: Deep-sequencing the built environment
      The Serious Science of Schmutz: Deep-sequencing the built environment
      The global trend towards industrialization and urbanization has led to ever more people living and working indoors. Some studies estimate that humans in industrialized countries spend as much...
      Speaker: Scott Kelley, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2016
      3
      SEP 08, 2016 | 9:00 AM
      Keynote Speaker: The Gut Microbiome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, A Neuroimmune Disease
      Keynote Speaker: The Gut Microbiome in Myalgic Encephalomyelitis/Chronic...
      ME/CFS is a debilitating disease with a controversial history and multiple names.  The Institute of Medicine recently recommended renaming the disease “Systemic Exertion Intoleranc...
      Speaker: Maureen Hanson
      Presented at: Microbiology & Immunology Virtual Event Series 2016
      2
      SEP 07, 2016 | 10:30 AM
      Exploring the Great Indoors: Relevance of the Built Environment to Human Health
      Exploring the Great Indoors: Relevance of the Built Environment...
      The human body is populated with trillions of microorganisms, collectively termed the human microbiome, that play vital roles in health including nutrition and metabolism, immune development,...
      Speaker: Roxana Hickey, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2016
      2
      SEP 07, 2016 | 6:00 AM
      Invisible Influence: How the indoor microbiome influences health
      Invisible Influence: How the indoor microbiome influences health
      The human race, like all macrobiological life, evolved in a sea of microbes. There was no way to keep the bacterial and archaeal hoards at bay, so instead life evolved mechanisms to live with...
      Speaker: Jack Gilbert, PhD
      Presented at: Microbiology & Immunology Virtual Event Series 2016
      2
      AUG 30, 2016 | 8:00 AM
      The matrix equation -  solving for the best pluripotent stem cell culture goals
      The matrix equation - solving for the best pluripotent stem cell...
      Access this training to learn more about the evolution of pluripotent stem cell culture systems and which solution is best for your PSC culture goals....
      Speaker: Rhonda Newman, PhD
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
      0
      AUG 30, 2016 | 8:00 AM
      Improved differentiation of human pluripotent stem cell-derived neurons through reduction of progenitor proliferation: impact on downstream applications
      Improved differentiation of human pluripotent stem cell-derived...
      Neurons derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are excellent resources for disease modeling and d...
      Speaker: David Kuninger, PhD
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
      1
      AUG 30, 2016 | 8:00 AM
      First Allogeneic Mesenchymal Stromal Cell Product Approved in India for Buerger's Disease - An Unmet Medical Need
      First Allogeneic Mesenchymal Stromal Cell Product Approved in...
      Buerger’s disease, commonly known as Thromboangiitis obliterans, is a non-atherosclerotic, segmental inflammatory disease that can affect the small and medium-sized arteries of young pe...
      Speaker: Anish Sen Majumbar, PhD
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      2
      AUG 30, 2016 | 8:00 AM
      Endoderm Progenitors in Health and Disease
      Endoderm Progenitors in Health and Disease
      Using human pluripotent stem cells as a screening platform, we have identified a novel cell surface maker that identifies foregut endoderm progenitors in pancreas and liver.  We have sho...
      Speaker: Martin Pera, PhD
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      1
      AUG 30, 2016 | 8:00 AM
      Transplanted human stem cell-derived interneuron precursors mitigate mouse bladder dysfunction and central neuropathic pain after spinal cord injury
      Transplanted human stem cell-derived interneuron precursors mitigate...
      Neuropathic pain and bladder dysfunction represent significant quality of life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to...
      Speaker: Cory Nicholas, PhD
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      1
      AUG 30, 2016 | 8:00 AM
      Human PSC-based disease modeling to study X-linked Dystonia-Parkinsonism
      Human PSC-based disease modeling to study X-linked Dystonia-Parkinsonism
      The isolation of human embryonic stem cells (hESCs) and the discovery of human induced pluripotent stem cell (hiPSC) reprogramming have sparked a renaissance in stem cell biology, in vitro di...
      Speaker: William Hendriks
      Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
      1
    FEB 07, 2017 | 10:00 AM
    WEBINAR: Beyond 100,000: Insights & Lessons from Large-Scale Sequencing in the Cloud
    WEBINAR: Beyond 100,000: Insights & Lessons from Large-Scale Sequencing...
    DATE: February 7, 2017TIME: 10:00am PT, 1:00pm ETIn this webinar, Jeffrey G. Reid, PhD, Executive Director and Head of Genome Informatics at Regeneron Pharmaceuticals, will sh...
    Speaker: Jeffrey Reid, PhD
    Sponsored By: DNAnexus
    13 3
    JAN 31, 2017 | 9:00 AM
    WEBINAR: Networks of exchanging antibiotic resistance across human commensal, environmental, and pathogenic bacteria
    WEBINAR: Networks of exchanging antibiotic resistance across human...
    DATE: January 31, 2017TIME: 9:00AM PT, 12:00PM ET Gautam Dantas - While the most acute effects of increasing antibiotic resistance in pathogens are observed in clinical se...
    Speaker: Gautam Dantas, PhD , Shuiquan Tang, PhD
    Sponsored By: Zymo Research, Zymo Research
    18 14
    JAN 27, 2017 | 4:00 AM
    WEBINAR: Highly Multiplexed Single Cell Analysis Of Tumor Heterogeneity Through Time and Space by Mass Cytometry
    WEBINAR: Highly Multiplexed Single Cell Analysis Of Tumor Heterogeneity...
    DATE: January 27, 2017TIME: 4:00am PT, 7:00am ET, 1:00pm CETThe study of the tumor ecosystem and its cell-to-cell communications is essential to enable an understanding of tumor biology...
    Speaker: Bernd Bodenmiller, PhD , Randall Wetzel, PhD
    Sponsored By: Cell Signaling Technology, Cell Signaling Technology
    16
    NOV 17, 2016 | 3:00 AM
    Genetic variability of ps-iPSC and related blood and fibroblasts - somatic mutations
    Genetic variability of ps-iPSC and related blood and fibroblasts...
    The generation of induced pluripotent stem cells (iPSCs) from adult easily accessible somatic tissues was introduced ten years ago. This technology has revolutionized our opportunities to stu...
    Speaker: KEYNOTE: Silke Rickert-Sperling, PhD
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    8 1
    NOV 16, 2016 | 4:00 PM
    Evolving your media system for modern stem cell applications
    Evolving your media system for modern stem cell applications
    Culture systems for pluripotent stem cell (PSC) expansion enable generation of a nearly unlimited pool of cells for downstream differentiation, disease modeling, drug discovery, and therapeut...
    Speaker: Rhonda Newman, PhD
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    4
     
     
  • NOV 16, 2016 | 8:00 AM
    The important role of lncRNAs in breast cancer
    The important role of lncRNAs in breast cancer
    DATE:  November 16, 2016 TIME:  8:00am PT, 11:00am ET  Breast cancer is the most commonly diagnosed cancer in women and is the second leading cause of cancer death among wo...
    Speaker: Rebecca DeVaux, PhD , Alfredo Hidalgo-Miranda, PhD
    Sponsored By: Affymetrix, Affymetrix
    8
    NOV 10, 2016 | 7:30 AM
    Does your protein analysis toolbox need a refresh?
    Does your protein analysis toolbox need a refresh?
    DATE:  November 10, 2016 TIME:  7:30am PT, 10:30am ET  Does your protein analysis toolbox need a refresh? Do you have a firm grasp on the tools available and when each migh...
    Speaker: Rich Jones, PhD
    Presented at: Beckman Coulter Life Sciences Virtual Trade Show
    Sponsored By: Beckman Coulter Life Sciences, Beckman Coulter Life Sciences
    4
    NOV 03, 2016 | 6:00 AM
    Automation and core-laboratory: experience of a large European academic hospital
    Automation and core-laboratory: experience of a large European...
    Core or central laboratory are facing several challenges. First, the management and operations of a successful modern laboratory is a real complex exercise, with multiple pre- and post-analyt...
    Speaker: Damien Gruson, PhD
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2016
    2
    NOV 02, 2016 | 9:00 AM
    Vitamin D supplementation in Pregnant Women: Effects on Preeclampsia and Asthma in the Offspring
    Vitamin D supplementation in Pregnant Women: Effects on Preeclampsia...
    Vitamin D insufficiency and deficiency are prevalent worldwide, and pregnant women and infants are at highest risk for having deficiency and related consequences. Epidemiologic studies have s...
    Speaker: Augusto Litonjua, MD, PhD , Scott Weiss, MD, MS
    Presented at: Clinical Diagnostics & Research Virtual Event Series 2016
    4
    OCT 06, 2016 | 10:30 AM
    Decoding human tumors and healthy tissue with mass cytometry
    Decoding human tumors and healthy tissue with mass cytometry
    New generations of treatments successfully target cancer cell signaling and modulate anti-cancer immunity to improve outcomes for advanced-stage malignancies. Such clinical responses are gove...
    Speaker: Jonathan Irish, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
    0
     
     
  • OCT 06, 2016 | 7:30 AM
    Keynote Speaker: Reference Component Analysis of Single Cell Transcriptomes Reveals Cellular Heterogeneity in Colorectal Cancer
    Keynote Speaker: Reference Component Analysis of Single Cell Transcriptomes...
    Intra-tumor heterogeneity is a major obstacle to cancer treatment. Existing single-cell studies of intra-tumor heterogeneity have largely focused on DNA mutations; functional heterogeneity is...
    Speaker: Shyam Prabhakar, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
    2
    OCT 05, 2016 | 6:00 AM
    Melanoma - View from the Frontlines of Immunotherapy and Precision Medicine
    Melanoma - View from the Frontlines of Immunotherapy and Precision...
    Melanoma arises in the pigment producing cells (melanocytes) and is the deadliest of the skin cancers. It accounts for nearly 200,000 new cases of cancer each year worldwide and in the U.S. o...
    Speaker: Louise Perkins, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2016
    2
    OCT 04, 2016 | 8:00 AM
    Overcoming the Clinical Sample Bottleneck for Expression Studies
    Overcoming the Clinical Sample Bottleneck for Expression Studies
    DATE:  October 4, 2016 TIME:  8:00am PT, 11:00am ET Extracting robust expression data from clinical samples represents a unique opportunity to find actionable biomarkers. But it...
    Speaker: Mark Manary, MD , Sean Diehl, PhD
    Sponsored By: Affymetrix, Affymetrix
    4
    SEP 20, 2016 | 8:00 AM
    Use of Surface Plasmon Resonance for Probing Cell-Matrix Interactions
    Use of Surface Plasmon Resonance for Probing Cell-Matrix Interactions
    DATE: September 20, 2016 TIME: 8:00am PST, 11:00 EST Studies of cell-substrate interactions are important for an array of biotechnology applications.  The nature of specific, recepto...
    Speaker: Michael Hill
    Sponsored By: Ametek, Ametek , Ametek
    7 5
    SEP 08, 2016 | 10:30 AM
    The Serious Science of Schmutz: Deep-sequencing the built environment
    The Serious Science of Schmutz: Deep-sequencing the built environment
    The global trend towards industrialization and urbanization has led to ever more people living and working indoors. Some studies estimate that humans in industrialized countries spend as much...
    Speaker: Scott Kelley, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2016
    3
     
     
  • SEP 08, 2016 | 9:00 AM
    Keynote Speaker: The Gut Microbiome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, A Neuroimmune Disease
    Keynote Speaker: The Gut Microbiome in Myalgic Encephalomyelitis/Chronic...
    ME/CFS is a debilitating disease with a controversial history and multiple names.  The Institute of Medicine recently recommended renaming the disease “Systemic Exertion Intoleranc...
    Speaker: Maureen Hanson
    Presented at: Microbiology & Immunology Virtual Event Series 2016
    2
    SEP 07, 2016 | 10:30 AM
    Exploring the Great Indoors: Relevance of the Built Environment to Human Health
    Exploring the Great Indoors: Relevance of the Built Environment...
    The human body is populated with trillions of microorganisms, collectively termed the human microbiome, that play vital roles in health including nutrition and metabolism, immune development,...
    Speaker: Roxana Hickey, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2016
    2
    SEP 07, 2016 | 6:00 AM
    Invisible Influence: How the indoor microbiome influences health
    Invisible Influence: How the indoor microbiome influences health
    The human race, like all macrobiological life, evolved in a sea of microbes. There was no way to keep the bacterial and archaeal hoards at bay, so instead life evolved mechanisms to live with...
    Speaker: Jack Gilbert, PhD
    Presented at: Microbiology & Immunology Virtual Event Series 2016
    2
    AUG 30, 2016 | 8:00 AM
    The matrix equation -  solving for the best pluripotent stem cell culture goals
    The matrix equation - solving for the best pluripotent stem cell...
    Access this training to learn more about the evolution of pluripotent stem cell culture systems and which solution is best for your PSC culture goals....
    Speaker: Rhonda Newman, PhD
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
    0
    AUG 30, 2016 | 8:00 AM
    Improved differentiation of human pluripotent stem cell-derived neurons through reduction of progenitor proliferation: impact on downstream applications
    Improved differentiation of human pluripotent stem cell-derived...
    Neurons derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are excellent resources for disease modeling and d...
    Speaker: David Kuninger, PhD
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    Sponsored By: Thermo Fisher Scientific, Thermo Fisher Scientific
    1
     
     
  • AUG 30, 2016 | 8:00 AM
    First Allogeneic Mesenchymal Stromal Cell Product Approved in India for Buerger's Disease - An Unmet Medical Need
    First Allogeneic Mesenchymal Stromal Cell Product Approved in...
    Buerger’s disease, commonly known as Thromboangiitis obliterans, is a non-atherosclerotic, segmental inflammatory disease that can affect the small and medium-sized arteries of young pe...
    Speaker: Anish Sen Majumbar, PhD
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    2
    AUG 30, 2016 | 8:00 AM
    Endoderm Progenitors in Health and Disease
    Endoderm Progenitors in Health and Disease
    Using human pluripotent stem cells as a screening platform, we have identified a novel cell surface maker that identifies foregut endoderm progenitors in pancreas and liver.  We have sho...
    Speaker: Martin Pera, PhD
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    1
    AUG 30, 2016 | 8:00 AM
    Transplanted human stem cell-derived interneuron precursors mitigate mouse bladder dysfunction and central neuropathic pain after spinal cord injury
    Transplanted human stem cell-derived interneuron precursors mitigate...
    Neuropathic pain and bladder dysfunction represent significant quality of life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to...
    Speaker: Cory Nicholas, PhD
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    1
    AUG 30, 2016 | 8:00 AM
    Human PSC-based disease modeling to study X-linked Dystonia-Parkinsonism
    Human PSC-based disease modeling to study X-linked Dystonia-Parkinsonism
    The isolation of human embryonic stem cells (hESCs) and the discovery of human induced pluripotent stem cell (hiPSC) reprogramming have sparked a renaissance in stem cell biology, in vitro di...
    Speaker: William Hendriks
    Presented at: 4th Annual 24 Hours of Stem Cells™ virtual event
    1
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