Drug Discovery: drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability.
A problem facing the rapid growth of zebrafish as a model for human disease is a lack of qualified personnel that understand the benefits and limitations of fish culture. As this model gains...
The new animal facility is designed to breed and house rodents with the best quality of macro and micro environment and house the maximum possible number of rodents per sf2. This new facilit...
As the prevalence of the use of Zebrafish as an animal model continues its ballistic growth, the need for a better understanding of the factors that add up to success is needed. Topics cover...
The 2011 Guide for the Care and Use of Laboratory Animals has required that institutions place importance on assuring that staff working with animals are trained and competent to perform thei...
Education and training is closely linked to the quality of performance of all levels of LAS personnel and directly effects both the welfare of the animals used in research and the quality of...
The question of pain in fish has been subject to much debate and, since fish are a popular experimental model globally and commercially important in fisheries, recreational angling and aquac...
Regulations and guidelines governing the use of animals in research require minimization of pain and distress. However, pharmacologic treatments to prevent or alleviate pain can interfere wit...
The utility of dried blood spot (DBS) sampling technology for rodent colony health monitoring was investigated using a two-tiered approach. In the first approach, groups of mice and rats were...
The laboratory animal industry had expanded rapidly in China recently. It is critical to have a good basic understanding of the domestic laws and regulations involving laboratory animals if a...
For the purpose of ensuring research integrity, data reproducibility, and animal welfare, institutions that conduct animal research have the responsibility to evaluate vendors that provide la...
This presentation mainly includes 4 sections, the first one: introduction for CFDA/FDA GLP Regulation and analysis the difference. The second one: introduction of the most important responsi...
Monitoring the health of laboratory rodents is an important tool for improving the quality of animals used in research. However not all animal facilities have the same requirements, and an ex...
The popularity reached by the genetic manipulation of laboratory animals to create new models for studying human diseases, produced in turn, that the techniques for assisted reproduction cons...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
Although a growing body of evidence indicates that environmental enrichment (EE) facilitates normal development and behaviour in laboratory mice, few studies were conducted to demonstrate it...
Abnormal behavior commonly occurs in captive nonhuman primates. It differs from normal behavior in either kind or degree and consists of behaviors such as pacing, self-grasping, and self-inju...
It is increasingly recognized that the genetic background (i.e., all genomic sequences other than the gene(s) of interest) can have profound influences on the phenotype of an animal model. I...
With the growth and expansion of mouse and rat transgenic models in recent years, the demand for surgically altered models mimicking human diseases is growing at an amazing rate. Surgical pro...
Nonhuman primates in captivity are typically provided with a multitude of behavioral management opportunities, including naturalistic social groupings, foraging devices, complex physical envi...
Modern biomedical research greatly benefits from sophisticated techniques which can detect even the most subtle alterations between different individuals or groups. This has raised the bar fo...
Training for researchers using animals is a requirement in most European countries. However, somewhat surprisingly, the main actor in providing specific guidelines for such training is a scie...
This seminar will cover spontaneous diseases of Rhesus Macaques utilizing a systemic approach. It will consist of gross and histopathologic images of common pathologic conditions highlighting...
It is commonly recognized that technicians are the backbone of a successful animal research program. Unfortunately, the invisible contributions that they make as well as the valuable high lev...
Almost all discussion to date on the ethics of animal use in research has revolved around the balance of harms (to the animals) versus benefits (to us) associated with conducting the researc...
A problem facing the rapid growth of zebrafish as a model for human disease is a lack of qualified personnel that understand the benefits and limitations of fish culture. As this model gains...
The new animal facility is designed to breed and house rodents with the best quality of macro and micro environment and house the maximum possible number of rodents per sf2. This new facilit...
As the prevalence of the use of Zebrafish as an animal model continues its ballistic growth, the need for a better understanding of the factors that add up to success is needed. Topics cover...
The 2011 Guide for the Care and Use of Laboratory Animals has required that institutions place importance on assuring that staff working with animals are trained and competent to perform thei...
Education and training is closely linked to the quality of performance of all levels of LAS personnel and directly effects both the welfare of the animals used in research and the quality of...
The question of pain in fish has been subject to much debate and, since fish are a popular experimental model globally and commercially important in fisheries, recreational angling and aquac...
Regulations and guidelines governing the use of animals in research require minimization of pain and distress. However, pharmacologic treatments to prevent or alleviate pain can interfere wit...
The utility of dried blood spot (DBS) sampling technology for rodent colony health monitoring was investigated using a two-tiered approach. In the first approach, groups of mice and rats were...
The laboratory animal industry had expanded rapidly in China recently. It is critical to have a good basic understanding of the domestic laws and regulations involving laboratory animals if a...
For the purpose of ensuring research integrity, data reproducibility, and animal welfare, institutions that conduct animal research have the responsibility to evaluate vendors that provide la...
This presentation mainly includes 4 sections, the first one: introduction for CFDA/FDA GLP Regulation and analysis the difference. The second one: introduction of the most important responsi...
Monitoring the health of laboratory rodents is an important tool for improving the quality of animals used in research. However not all animal facilities have the same requirements, and an ex...
The popularity reached by the genetic manipulation of laboratory animals to create new models for studying human diseases, produced in turn, that the techniques for assisted reproduction cons...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
Although a growing body of evidence indicates that environmental enrichment (EE) facilitates normal development and behaviour in laboratory mice, few studies were conducted to demonstrate it...
Abnormal behavior commonly occurs in captive nonhuman primates. It differs from normal behavior in either kind or degree and consists of behaviors such as pacing, self-grasping, and self-inju...
It is increasingly recognized that the genetic background (i.e., all genomic sequences other than the gene(s) of interest) can have profound influences on the phenotype of an animal model. I...
With the growth and expansion of mouse and rat transgenic models in recent years, the demand for surgically altered models mimicking human diseases is growing at an amazing rate. Surgical pro...
Nonhuman primates in captivity are typically provided with a multitude of behavioral management opportunities, including naturalistic social groupings, foraging devices, complex physical envi...
Modern biomedical research greatly benefits from sophisticated techniques which can detect even the most subtle alterations between different individuals or groups. This has raised the bar fo...
Training for researchers using animals is a requirement in most European countries. However, somewhat surprisingly, the main actor in providing specific guidelines for such training is a scie...
This seminar will cover spontaneous diseases of Rhesus Macaques utilizing a systemic approach. It will consist of gross and histopathologic images of common pathologic conditions highlighting...
It is commonly recognized that technicians are the backbone of a successful animal research program. Unfortunately, the invisible contributions that they make as well as the valuable high lev...
Almost all discussion to date on the ethics of animal use in research has revolved around the balance of harms (to the animals) versus benefits (to us) associated with conducting the researc...
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