Clinical Research: Patient - oriented research. Clinical research is a branch of healthcare science that determines the safety and effectiveness (efficacy) of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatment, diagnosis or for relieving symptoms of a disease.
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack o...
The contemporary understanding of psychiatric disorders typically consists of a vast but often poorly interrelated set of facts and hypotheses that fail to coalesce into an integrated whole....
Substantial evidence demonstrates that schizophrenia involves a dysregulated dopamine system, potentially driven by overactivity in the hippocampus. Postmortem studies of schizophrenia brains...
Deep brain stimulation (DBS) is an established therapy for cardinal motor signs and medication-related complications in Parkinson’s disease (PD). Current DBS therapy is limited to &ldqu...
Plasticity in the brain is very extensive due to the brain’s parallel architecture and synaptic reorganization capabilities. Because neuronal populations are typically in stable low e...
Actions are not mediated solely by cortical processes but rely on communication within basal ganglia-thalamocortical loops. Speech is one example, although how the basal ganglia participate i...
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high-frequency stim...
Neurotechnology promises a way to repair the damaged nervous system that requires a merger of neuroscience, engineering and clinical knowledge. Brain Computer Interfaces can now read out the...
Localizing and identifying neuronal patterns that generate pathological brain signals may assist with tissue resection and intervention strategies in patients with neurological and psychiatri...
Systems neuroscience offers new and powerful conceptual frameworks for testing the fundamental brain mechanisms that support behavior. More recently, modern neurotechnologies with translation...
Direct recording of neural activity from the human brain (intracranial encephalography, iEEG, also known as electrocorticography, ECoG) using implanted electrodes is one of the fastest-growin...
Stimulation of human visual cortex is known to elicit visual perceptions that could potentially be used for restoring artificial vision to individuals who have lost their vision due to non-co...
This talk provides a brief overview of funding opportunities for invasive device development for translation to clinical populations supported by the NIH BRAIN Initiative....
The implications of NIH BRAIN research stretch beyond traditional medical and research contexts. This LabRoots session will present recent developments at the intersection of neuroscience and...
What motivates patients to participate in clinical trials? Discussions most often revolve around potential study participants’ perception of therapeutic benefit. Misconceptions about th...
Developing new diagnostic and therapeutic tools for brain disorders is an ethical imperative and conducting human research with neural devices is a key step towards achieving that goal. Condu...
The NIH BRAIN Initiative aims to develop new tools and neurotechnologies to transform our understanding of brain function in health and disease. That knowledge is critical to enable novel the...
Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this cognitive flexibility is our ability to perform complex, yet previously un-pract...
Humans interact with their environment in countless ways and can switch seamlessly between activities. Even for seemingly simple tasks, a variety of sensory inputs and contextual cues are int...
The rapid formation of new memories and the recall of old memories to inform decisions is essential for human cognition, but the underlying neural mechanisms remain poorly understood. We util...
The human brain has a remarkable ability to store and retrieve information. Detailed memories can be formed after as little as one exposure, and those memories can be retained for decades. Im...
NIH representatives from the BRAIN Initiative will be presenting an overview of the NIH BRAIN Initiative and describing funding opportunity announcements (FOAs) supporting impacts in human ne...
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, due to a lack o...
The contemporary understanding of psychiatric disorders typically consists of a vast but often poorly interrelated set of facts and hypotheses that fail to coalesce into an integrated whole....
Substantial evidence demonstrates that schizophrenia involves a dysregulated dopamine system, potentially driven by overactivity in the hippocampus. Postmortem studies of schizophrenia brains...
Deep brain stimulation (DBS) is an established therapy for cardinal motor signs and medication-related complications in Parkinson’s disease (PD). Current DBS therapy is limited to &ldqu...
Plasticity in the brain is very extensive due to the brain’s parallel architecture and synaptic reorganization capabilities. Because neuronal populations are typically in stable low e...
Actions are not mediated solely by cortical processes but rely on communication within basal ganglia-thalamocortical loops. Speech is one example, although how the basal ganglia participate i...
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high-frequency stim...
Neurotechnology promises a way to repair the damaged nervous system that requires a merger of neuroscience, engineering and clinical knowledge. Brain Computer Interfaces can now read out the...
Localizing and identifying neuronal patterns that generate pathological brain signals may assist with tissue resection and intervention strategies in patients with neurological and psychiatri...
Systems neuroscience offers new and powerful conceptual frameworks for testing the fundamental brain mechanisms that support behavior. More recently, modern neurotechnologies with translation...
Direct recording of neural activity from the human brain (intracranial encephalography, iEEG, also known as electrocorticography, ECoG) using implanted electrodes is one of the fastest-growin...
Stimulation of human visual cortex is known to elicit visual perceptions that could potentially be used for restoring artificial vision to individuals who have lost their vision due to non-co...
This talk provides a brief overview of funding opportunities for invasive device development for translation to clinical populations supported by the NIH BRAIN Initiative....
The implications of NIH BRAIN research stretch beyond traditional medical and research contexts. This LabRoots session will present recent developments at the intersection of neuroscience and...
What motivates patients to participate in clinical trials? Discussions most often revolve around potential study participants’ perception of therapeutic benefit. Misconceptions about th...
Developing new diagnostic and therapeutic tools for brain disorders is an ethical imperative and conducting human research with neural devices is a key step towards achieving that goal. Condu...
The NIH BRAIN Initiative aims to develop new tools and neurotechnologies to transform our understanding of brain function in health and disease. That knowledge is critical to enable novel the...
Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this cognitive flexibility is our ability to perform complex, yet previously un-pract...
Humans interact with their environment in countless ways and can switch seamlessly between activities. Even for seemingly simple tasks, a variety of sensory inputs and contextual cues are int...
The rapid formation of new memories and the recall of old memories to inform decisions is essential for human cognition, but the underlying neural mechanisms remain poorly understood. We util...
The human brain has a remarkable ability to store and retrieve information. Detailed memories can be formed after as little as one exposure, and those memories can be retained for decades. Im...
NIH representatives from the BRAIN Initiative will be presenting an overview of the NIH BRAIN Initiative and describing funding opportunity announcements (FOAs) supporting impacts in human ne...
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