Clinical Diagnostics: The identification of a disease in regards to a patient's complaints based merely on signs, symptoms, and medical history of the patient rather than on laboratory examination or medical imaging.
Central to the diagnosis and management of patients with diabetes mellitus is the measurement of hemoglobin A1c (HbA1c). Major studies have defined the therapeutic targets of HbA1c in order...
Applying machine learning methods to structured, expert-curated content from scientific literature is a powerful way to discover latent knowledge. Building on the QIAGEN Knowledge Base, we us...
70,237 drug overdose deaths occurred in the United States in 2017 and opioids were involved in 47,600 of those deaths (67.8%).1 Ohio had the second highest rate of opioid overdose deaths in t...
Burn patients are at risk for organ dysfunction secondary to “burn shock” and sepsis. The initial 24 hours following major burn injury presents with significant hypotension due to...
Facioscapulohumeral muscular dystrophy (FSHD), one of the most common forms of progressive muscular dystrophies and is often conventionally diagnosed by Southern blot analysis. The accurate d...
Despite FDA-approved vaccines and antivirals, seasonal and pandemic influenza remains a serious threat associated with substantial morbidity and mortality. The present modalities and vaccine...
Respiratory viral infections remain a leading cause of medical visits and can contribute significantly to morbidity and mortality. Influenza, together with pneumonia, is the leading infectiou...
Influenza viruses are transmitted by membrane-bound virus particles, or virions. Unlike some viruses, which produce near-identical virions from a well-defined set of viral components, influen...
The efficacy of current influenza antiviral drugs is compromised by emerging drug resistance. To address this unmet medical need, we have made progress in developing novel influenza antiviral...
To prepare for the 2019 flu season it is important to get immunized. In 2019 a tetravalent (four-virus) vaccine is available in a number of forms including an egg-free formulation that is for...
Since the establishment of reverse genetics techniques to manipulate the influenza virus genome, it has been possible to study viral molecular signatures responsible for virulence, and the ge...
Multiple factors can affect and impact infection dynamics and virulence produced by influenza virus (IV) infections. Susceptibility factors and host responses can also have major effects in d...
DATE: November 5, 2019 TIME: 7:00am PST, 9:00am CSTDetection of low-abundance proteins and/or detection of proteins from precious samples can be a major challenge when performing wes...
DATE: October 31, 2019TIME: 9:00am PDT, 12:00pm EDT INTRODUCTION: A major limitation for the development of 3D engineered tissues is the absence of viable and perfusable...
DATE: October 29, 2019TIME: 09:00am PDTTrichomonas vaginalis and Mycoplasma genitalium are common sexually transmitted infections (STIs) yet are not as well studied or understood as gon...
DATE: October 22, 2019TIME: 10:00am PDTNext-generation sequencing (NGS) is quickly becoming the go-to tool for testing labs looking to bring on additional clinically relevant tests requ...
Calprotectin is a member of the S100 family of calcium binding proteins, being a hetero dimmer of S100A8/9 and accounts for 60% of the protein in the cytoplasm of neutrophils. It is released...
Metastatic castration resistant prostate cancer (mCRPC) refractory to secondary hormonal treatments such as enzalutamide or abiraterone acetate are the most lethal of prostate cancers. In thi...
Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...
Accumulation of structural variations (SVs) across the genome is a known trigger factor for oncogenesis. Structural mutations have been clearly implicated in a number of cancers, most notably...
Osteosarcoma (OS) is the most common bone tumor in pediatric and adolescent/young adult patients. Over the past three decades, significant improvements in the survival rates or therapeutic ap...
Copy-number alterations and chromosomal translocations are widespread in cancer and frequently causing oncogenic mutations that drive tumorigenesis and therapy resistance. Despite their preva...
Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family...
Central to the diagnosis and management of patients with diabetes mellitus is the measurement of hemoglobin A1c (HbA1c). Major studies have defined the therapeutic targets of HbA1c in order...
Applying machine learning methods to structured, expert-curated content from scientific literature is a powerful way to discover latent knowledge. Building on the QIAGEN Knowledge Base, we us...
70,237 drug overdose deaths occurred in the United States in 2017 and opioids were involved in 47,600 of those deaths (67.8%).1 Ohio had the second highest rate of opioid overdose deaths in t...
Burn patients are at risk for organ dysfunction secondary to “burn shock” and sepsis. The initial 24 hours following major burn injury presents with significant hypotension due to...
Facioscapulohumeral muscular dystrophy (FSHD), one of the most common forms of progressive muscular dystrophies and is often conventionally diagnosed by Southern blot analysis. The accurate d...
Despite FDA-approved vaccines and antivirals, seasonal and pandemic influenza remains a serious threat associated with substantial morbidity and mortality. The present modalities and vaccine...
Respiratory viral infections remain a leading cause of medical visits and can contribute significantly to morbidity and mortality. Influenza, together with pneumonia, is the leading infectiou...
Influenza viruses are transmitted by membrane-bound virus particles, or virions. Unlike some viruses, which produce near-identical virions from a well-defined set of viral components, influen...
The efficacy of current influenza antiviral drugs is compromised by emerging drug resistance. To address this unmet medical need, we have made progress in developing novel influenza antiviral...
To prepare for the 2019 flu season it is important to get immunized. In 2019 a tetravalent (four-virus) vaccine is available in a number of forms including an egg-free formulation that is for...
Since the establishment of reverse genetics techniques to manipulate the influenza virus genome, it has been possible to study viral molecular signatures responsible for virulence, and the ge...
Multiple factors can affect and impact infection dynamics and virulence produced by influenza virus (IV) infections. Susceptibility factors and host responses can also have major effects in d...
DATE: November 5, 2019 TIME: 7:00am PST, 9:00am CSTDetection of low-abundance proteins and/or detection of proteins from precious samples can be a major challenge when performing wes...
DATE: October 31, 2019TIME: 9:00am PDT, 12:00pm EDT INTRODUCTION: A major limitation for the development of 3D engineered tissues is the absence of viable and perfusable...
DATE: October 29, 2019TIME: 09:00am PDTTrichomonas vaginalis and Mycoplasma genitalium are common sexually transmitted infections (STIs) yet are not as well studied or understood as gon...
DATE: October 22, 2019TIME: 10:00am PDTNext-generation sequencing (NGS) is quickly becoming the go-to tool for testing labs looking to bring on additional clinically relevant tests requ...
Calprotectin is a member of the S100 family of calcium binding proteins, being a hetero dimmer of S100A8/9 and accounts for 60% of the protein in the cytoplasm of neutrophils. It is released...
Metastatic castration resistant prostate cancer (mCRPC) refractory to secondary hormonal treatments such as enzalutamide or abiraterone acetate are the most lethal of prostate cancers. In thi...
Tumor mutational burden (TMB) is an emerging biomarker that correlates with response to immunotherapeutic agents, such as checkpoint inhibitors. Recent studies indicate that a high mutation l...
Accumulation of structural variations (SVs) across the genome is a known trigger factor for oncogenesis. Structural mutations have been clearly implicated in a number of cancers, most notably...
Osteosarcoma (OS) is the most common bone tumor in pediatric and adolescent/young adult patients. Over the past three decades, significant improvements in the survival rates or therapeutic ap...
Copy-number alterations and chromosomal translocations are widespread in cancer and frequently causing oncogenic mutations that drive tumorigenesis and therapy resistance. Despite their preva...
Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family...
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