Chemical Biology: a scientific discipline spanning the fields of chemistry, biology, and physics. It involves the application of chemical techniques, tools, and analyses, and often compounds produced through synthetic chemistry, to the study and manipulation of biological systems. Chemical biologists attempt to use chemical principles to modulate systems to either investigate the underlying biology or create new function. Chemicals - including natural small molecules, such as lipids, carbohydrates and metals, or non-natural probe or drug molecules - are used to gain insight into biological problems at a mechanistic level.
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The dopamine D4 receptor (D4R) is enriched in the prefrontal cortex where it plays important roles in cognition, attention, decision making and executive function. Novel D4R-selective ligand...
DATE: December 4, 2019 TIME: 9:00am PST, 12:00pm EST Targeted protein degradation is a novel chemical modality centered on using pharmacological agents to immediately and select...
DATE: December 4, 2019TIME: 7:00am PST, 10:00am EST, 4:00pm CET Do you know how it feels when you just quickly want to redo an experiment that your colleague did, or an experim...
DATE: November 19, 2019TIME: 8:00am PTCentrifugation has long served as a critical separation tool in countless research and production facilities spanning a wide range of discipline...
DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
DATE: October 30, 2019TIME: 7:00am PDTJoin us for a webinar to learn how to apply single cell methods to study cancer. Dr. William Greenleaf, Associate Professor from Stanford Universit...
DATE: October 16, 2019TIME: 9:00am PDTManual titrations can be extremely challenging and frustrating, impeding your efficiency in the lab. More importantly, these issues can lead to inc...
Copy-number alterations and chromosomal translocations are widespread in cancer and frequently causing oncogenic mutations that drive tumorigenesis and therapy resistance. Despite their preva...
DATE: September 30, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Expression quantitative trait loci (eQTLs) are SNPs that have an influence on expression levels of genes, and the ident...
DATE: September 27, 2019TIME: 9:00am PT, 12:00pm ET Thienopyrazole derivatives have recently emerged as effective antitumoral agents with kinase inhibitory activity. In this s...
The ability to discern spatial gene expression differences in complex biological systems is critical to our understanding of developmental biology and the progression of disease. However, the...
DATE: September 24, 2019TIME: 7:00am PDTHigh throughput screening (HTS) is an effective method for identifying putative active compounds for therapeutics. Assays that evaluate changes i...
Contemporary law enforcement has greatly expanded its ability to solve crimes by the adoption of advanced forensic techniques, electronic monitoring and new approaches in crime scene procedur...
Prediction of human response to chemical exposures is the primary challenge of pharmaceutical and environmental toxicology research. The complexity of human responses to xenobiotic exposures...