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Animal disease model development
Animal disease models are non-human animals used to research strategies to detect, prevent, or treat human disease. A variety of animals, including mice, rats, rabbits, and non-human primates are used for animal disease modeling. New animal disease models are developed regularly as knowledge of disease expand and technological improvements enhance current models.
OCT 03, 2018 | 12:00 PM
Decoding human genetic disease allows us to develop models of the pathology that can be directly tested with gene correction or targeted drug therapy. Dominant negative mutations are pa...
OCT 03, 2018 | 10:30 AM
There have been an increasing number of successful human gene therapy clinical trials, and in particular gene delivery vehicles or vectors based on the adeno-associated virus (AAV) have enabl...
AUG 01, 2018 | 12:00 AM
Induced pluripotent stem (iPS) cells are a promising source of personalized therapy. These cells can provide immune-compatible autologous replacement tissue for the treatment of potentially a...
JUL 19, 2018 | 9:00 AM
DATE: July 19, 2018TIME: 09:00am PDT Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5 year-survival rate of approximately 6%. Despite recent...
JUN 29, 2018 | 9:00 AM
DATE: June 29, 2018TIME: 09:00AM PDT, 12:00PM EDT There is significant epidemiological evidence to suggest that the consumption of a high-broccoli diet is associated with a r...
JUN 26, 2018 | 9:00 AM
Treatments for respiratory diseases represent an enormous, unmet medical need with limited therapies currently approved for use. Despite many compounds demonstrating beneficial effects in ani...
MAY 30, 2018 | 6:00 AM
The pharmaceutical industry’s productivity crisis is well known with >90% of drug candidates failing in clinical testing, primarily due to unexpected toxicity or lack of efficacy. &n...
MAY 22, 2018 | 8:00 AM
DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
MAY 09, 2018 | 12:00 PM
In this presentation I will describe results from a family study designed to identify the genetic cause for familial clustering of several early onset cancers. Data from next generatio...
MAR 27, 2018 | 9:00 AM
DATE: March 27, 2018TIME: 09:00am PDT, 12:00pm EDTThe rapid adoption and ease of use of CRISPR-Cas9 has driven the development of applications for gene knockout, precise gene editing, a...
MAR 22, 2018 | 9:00 AM
DATE: March 22, 2018TIME: 09:00am PST, 12:00pm ESTGlioblastoma (GBM) is the most aggressive primary brain cancer, with nearly universal recurrence after treatment. GBMs are highly heter...
MAR 15, 2018 | 10:30 AM
The study of rare, neurological disorder and the development of effect treatments can pose many unique challenges. A paucity of scientists working on these disorders often limits forward prog...
MAR 14, 2018 | 10:30 AM
Since its initial description more than 70 years ago, autism spectrum disorder (ASD) has been diagnosed more frequently in boys. However, we remain unsure of why males are affected in greater...
MAR 14, 2018 | 9:00 AM
Biomedical research depends on the use of model systems to explore basic biology, probe disease mechanisms, and conduct drug discovery and development. However, results from such systems are...
