Analytical research and development (AR&D) involves numerous processes required for drug development. AR&D includes processes such as reference standard qualification, validation of analytical methods, stability and degradation studies, and product testing.
At Biogen Idec, we have implemented a 3 part innovation operating model which includes innovation mentoring, agile experimentation and transition of experiments into pilots. In this presenta...
Colloidal nanoparticles have become important materials in biomedicine, catalysis, and optoelectronics. Their unique nanoscale properties stem from their size (particularly of the i...
The comprehensive, multidimensional molecular characterization of tumors and the individuals in which they have developed is transforming cancer definition, diagnosis, treatment, and preventi...
In this presentation I describe pathway based analyses of genotyping data to identify pathways related to the development of complex diseases, with a focus on lung cancer and selected autoimm...
A recent publication in Nature Genetics1 analyzed TCGA data, and classified solid tumors into two mutually exclusive classes: C class tumors, driven by copy number alterations; and M class tu...
Next-generation sequencing (NGS) has revolutionized extraction of genomic information, facilitating rapid advances in the fields of clinical research and molecular diagnostics. However, c...
As next-generation sequencing (NGS) platforms advance in their speed, ease-of-use, and cost-effectiveness, many translational researchers are transitioning from microarrays to RNA sequencing...
Pharmcogenomics (PGx) is the 2nd potential clinical application of genomic medicine, preceded by genomic application for cancer. In the recently published, 2012 Institute of Medicine report o...
Clinical laboratory information provides decision support for most healthcare providers and impacts care processes and patient outcomes throughout the entire health services delivery system....
Governments, pathology providers, and clients relying on pathology reports face increasing conflict between burgeoning costs versus demands for service innovation. The health industry has bee...
Traditional testing methods for monoclonal protein in Plasma Cell Dyscrasias correctly identify a majority of patients. However, limitations in these methods can cause patients to be missed...
Guidelines for physicians treating pain patients with chronic opioid therapy recommend the patients be monitored for the presence of their prescribed medications. In addition, it is often rec...
Six-Sigma quality is defined as 3.4 (or fewer) defects per million opportunities (DPMO). Achieving Six-Sigma quality in a clinical laboratory is extremely difficult. This presentation will sh...
Variability of vitamin D results remains a hot topic today as more options are available to laboratories. This webinar examines how clinical and analytical factors such as vitamin D binding...
Neuroimaging plays a large role in our pursuit of the understanding of behavior and cognition in health and disease. The past decade has seen the emergence of a wealth of resources that suppo...
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
The discovery of proteinaceous disease biomarkers and their clinical validation is critically important for the enablement of molecular diagnostics and ultimately, precision medicine. In spit...
Personalized medicine is transforming biomedical research and healthcare service delivery. Disease definition, diagnosis, treatment, and prevention are being fundamentally altered by the capa...
Many drugs currently used for anti-cancer therapy demonstrate significant inter-individual variability that cannot be normalized using body weight or body surface area. There is an increasing...
The current paradigm of detecting established cancer (often too late) and treating routinely with cytotoxic drugs is beginning to change. Advanced technologies such as whole genome sequencin...
The use of ultrahigh throughput diagnostic tests that determine genetic sequence variation to guide patient care is rapidly expanding, fueled by the enormous growth in sequencing platform dev...
Personalized medicine is transforming biomedical research and healthcare service delivery. Disease definition, diagnosis, treatment, and prevention are being fundamentally altered by the capa...
Approximately 98% of the human genome comprises noncoding DNA, the function of which is largely unknown. Intriguingly, more than 85% of single nucleotide polymorphisms identified to be associ...
At Biogen Idec, we have implemented a 3 part innovation operating model which includes innovation mentoring, agile experimentation and transition of experiments into pilots. In this presenta...
Colloidal nanoparticles have become important materials in biomedicine, catalysis, and optoelectronics. Their unique nanoscale properties stem from their size (particularly of the i...
The comprehensive, multidimensional molecular characterization of tumors and the individuals in which they have developed is transforming cancer definition, diagnosis, treatment, and preventi...
In this presentation I describe pathway based analyses of genotyping data to identify pathways related to the development of complex diseases, with a focus on lung cancer and selected autoimm...
A recent publication in Nature Genetics1 analyzed TCGA data, and classified solid tumors into two mutually exclusive classes: C class tumors, driven by copy number alterations; and M class tu...
Next-generation sequencing (NGS) has revolutionized extraction of genomic information, facilitating rapid advances in the fields of clinical research and molecular diagnostics. However, c...
As next-generation sequencing (NGS) platforms advance in their speed, ease-of-use, and cost-effectiveness, many translational researchers are transitioning from microarrays to RNA sequencing...
Pharmcogenomics (PGx) is the 2nd potential clinical application of genomic medicine, preceded by genomic application for cancer. In the recently published, 2012 Institute of Medicine report o...
Clinical laboratory information provides decision support for most healthcare providers and impacts care processes and patient outcomes throughout the entire health services delivery system....
Governments, pathology providers, and clients relying on pathology reports face increasing conflict between burgeoning costs versus demands for service innovation. The health industry has bee...
Traditional testing methods for monoclonal protein in Plasma Cell Dyscrasias correctly identify a majority of patients. However, limitations in these methods can cause patients to be missed...
Guidelines for physicians treating pain patients with chronic opioid therapy recommend the patients be monitored for the presence of their prescribed medications. In addition, it is often rec...
Six-Sigma quality is defined as 3.4 (or fewer) defects per million opportunities (DPMO). Achieving Six-Sigma quality in a clinical laboratory is extremely difficult. This presentation will sh...
Variability of vitamin D results remains a hot topic today as more options are available to laboratories. This webinar examines how clinical and analytical factors such as vitamin D binding...
Neuroimaging plays a large role in our pursuit of the understanding of behavior and cognition in health and disease. The past decade has seen the emergence of a wealth of resources that suppo...
The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
The discovery of proteinaceous disease biomarkers and their clinical validation is critically important for the enablement of molecular diagnostics and ultimately, precision medicine. In spit...
Personalized medicine is transforming biomedical research and healthcare service delivery. Disease definition, diagnosis, treatment, and prevention are being fundamentally altered by the capa...
Many drugs currently used for anti-cancer therapy demonstrate significant inter-individual variability that cannot be normalized using body weight or body surface area. There is an increasing...
The current paradigm of detecting established cancer (often too late) and treating routinely with cytotoxic drugs is beginning to change. Advanced technologies such as whole genome sequencin...
The use of ultrahigh throughput diagnostic tests that determine genetic sequence variation to guide patient care is rapidly expanding, fueled by the enormous growth in sequencing platform dev...
Personalized medicine is transforming biomedical research and healthcare service delivery. Disease definition, diagnosis, treatment, and prevention are being fundamentally altered by the capa...
Approximately 98% of the human genome comprises noncoding DNA, the function of which is largely unknown. Intriguingly, more than 85% of single nucleotide polymorphisms identified to be associ...
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