Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Director, NHLBI
Professor, Department of Nutrition and Exercise Physiology, University of Missouri School of Medicine
Professor of Health Policy and Management at the City University of New York (CUNY) School of Public Health where he is the Executive Director of PHICOR
Director of Nutrition and Genomics Lab. JM-USDA-HNRCA at Tufts Univ. and Professor, Friedman School of Nutrition Science and Policy
Director, Alzheimer's Prevention Clinic Assistant Dean, Faculty Development Weill Cornell Medicine / NewYork-Presbyterian
Professor of Population Health and Medicine, Grossman School of Medicine, New York University
Professor and Endowed Chair/Director, Linus Pauling Institute, Oregon State University
Professor and Chief, Nutrition Division, Department of Preventive Medicine
Pennington Biomedical Research Center
Professor, Medical Oncology, The Ohio State University
Professor of Genetic Epidemiology
Senior Scientist & Director Nutritional Immunology Lab & JM USDA Human Nutrition Research..., Professor of Nutrition, Professor of Immunology at Tufts
Program Director, Office of Nutrition Research, NIH
Professor, Fred Hutchinson Cancer Research Center
Full Professor of Nutrition & Nutrigenomics University College Dublin
Professor of Medicine, Harvard Medical School; Director, Medical Chronobiology Program, Brigham and Women's Hospital
Donald and Sue Priztker Associate Professor of Nutrition; Harvard TH Chan School of Public Health
Professor and Dean, UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science; Director Center of Excellence in Health Behavior and Equity
Robert Gray Dodge Professor of Network Science
Professor & Director of the Graduate Program in Allied Health Sciences Department of Allied Health Science
Associate Professor of Nutrition, University of North Carolina at Chapel Hill
Professor of Nutrition
Research Associate Professor University of Chicago
Assistant Professor, Rory Meyers College of Nursing, New York University
Office of Behavioral and Social Sciences Research, NIH
Research Investigator, HealthPartners Institute
Associate Director for Data Science, NIH
Doctoral Student in Epidemiology, Stanford University School of Medicine
Program Director for Data Science Workforce Development, Office of Data Science Strategy
Associate Professor, Department of Epidemiology & Population Health Stanford University School of Medicine
National Human Genome Research Institute
Assistant Professor of Preventive Medicine, University of Southern California
Director of the Machine Learning and Healthcare Lab and John C. Malone Associate Professor of Computer Science, Statistics, and Public Health, Johns Hopkins University...
Northwestern University McCormick School of Engineering
President and Chief Science Officer, HealthPartners Institute Affiliate Professor, University of Minnesota School of Public Health Visiting Scientist, Harvard Chan School of Public Health
Assistant Professor of Medical Ethics, Director of Transplant Ethics and Policy Research; NYU Grossman School of Medicine
Professor at the Department of Computer Science and Applied Mathematics at the Weizmann Institute of Science
FRCP, King's College London
Postdoctoral Research Fellow, Department of Preventive Medicine, Division of Biostatistics, University of Southern California
Director of Mathematical Modeling, Simulation and Analysis, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Background
The science of precision nutrition is a holistic approach to developing comprehensive and dynamic nutrition recommendations relevant to both individual and population health. It is a framework in research and practice that considers multiple, synergistic levels of influence: dietary habits, genetic background, health status, microbiome, metabolism, food environment, physical activity, socioeconomics, psychosocial characteristics, and environmental exposures.
Objectives
A primary goal of the field of precision nutrition is to optimize metabolic response in individuals or population subgroups through tailored dietary approaches to promote health and prevent and treat disease. Many factors, including all levels of influence mentioned above, affect individuals’ physiologic responses to diet. Precision nutrition science enables individualized dietary recommendations or therapies based on these factors. This workshop will bring together scientists with diverse expertise to explore how best to address these complex factors. It also will focus on diet-related chronic diseases and how artificial intelligence (AI) and deep-learning techniques may be used to generate individualized dietary recommendations and algorithms. Opportunities for research and training of the next generation of future researchers in the field of precision nutrition will be discussed.
Co-Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institutes of Health (NIH) Office of Disease Prevention (ODP)
Meeting Co-Chairs
José Ordovás, Ph.D., Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Elizabeth Parks, Ph.D., Institute for Clinical Translational Science, University of Missouri School of Medicine
Bruce Y. Lee, M.D., MBA, City University of New York School of Public Health
Organizing Committee
Josephine Boyington, Ph.D., M.P.H., NHLBI
Andrew Bremer, M.D., Ph.D., Eunice Kennedy Shriver National Institute of Child Health and Human Development
Allison Brown, Ph.D., NHLBI
Christopher Lynch, Ph.D., NIDDK
Holly Nicastro, Ph.D., M.P.H., NIDDK
Charlotte Pratt, Ph.D., R.D., NHLBI
Jill Reedy, Ph.D., M.P.H., R.D., National Cancer Institute (NCI)
Karen Regan, M.S., R.D., NIDDK
Scarlet Shi, Ph.D., NHLBI
Pothur Srinivas, Ph.D., M.P.H., NCI
Ashley Vargas, Ph.D., M.P.H., R.D.N., NICHD
January 11, 2021
______________________________________________________________________________
9:00 a.m. – 9:25 a.m.
Opening Remarks
Griffin P. Rodgers, M.D., MACP, Director, NIDDK, NIH
Gary H. Gibbons, M.D., Director, National Heart, Lung, and Blood Institute, NIH
Section 1: Precision Nutrition Science in Diet-related Chronic Diseases
Moderator: José Ordovás, Ph.D.
Poor nutrition is a crucial risk factor for a host of chronic diseases and conditions that are the leading causes of death and disability in the United States—including cardiovascular disease and stroke, type 2 diabetes, obesity, cancers, and others—with associated health care costs estimated to be in the hundreds of billions of dollars annually. Many studies have revealed huge differences in disease risk and biological responses to diet among individuals. Although those differences were initially thought to be driven by genetics, the current findings support the crucial combined roles of genetics, behavioral, sociological, environmental, and economic factors as response modifiers, making it challenging to fully answer the practical question of what to eat to stay healthy, which requires moving beyond a one-size-fits-all dietary recommendation for optimal health and disease prevention. Section 1 of the meeting will have focused discussions on dietary approaches to address the most common chronic diseases in our society and will be followed by panel discussions on critical research questions, gaps, and opportunities in precision nutrition science to address individual variability in dietary patterns across the life span.
9:25 a.m. – 9:30 a.m.
Moderator Introduction
9:30 a.m. – 9:45 a.m.
Cardiovascular Disease
José Ordovás, Ph.D., Jean Mayer U.S. Departure of Agriculture Human Nutrition Research Center on Aging, Tufts University
9:45 a.m. – 10:00 a.m.
Cognitive Function
Richard Isaacson, M.D., Weill Cornell Medical College
10:00 a.m. – 10:15 a.m.
Diabetes/Impaired Glucose Regulation
Mary Ann Sevick, Sc.D., New York University Grossman School of Medicine
10:15 a.m. – 10:30 a.m.
Cancer: Primary and Secondary Prevention
Emily Ho, Ph.D., Oregon State University
10:30 a.m. – 11:30 a.m.
Section 1 Q & A and Panel Discussion: Research Gaps and Opportunities (Live)
Linda Van Horn, Ph.D., RD, Northwestern University Feinberg School of Medicine
Corby Martin, Ph.D., Pennington Biomedical Research Center
Steven Clinton, M.D., Ph.D., The Ohio State University
Paul Franks, Ph.D., Lund University
Simin Nikbin Meydani, Ph.D., D.V.M. Tufts University
11:30 a.m. – 11:45 a.m.
Break and Poster Session
Section 2: NIH Interest in the Field of Precision Nutrition
11:45 a.m. – 12:15 p.m.
Planning for Nutrition for Precision Health, Powered by the All of Us Research Program
Holly Nicastro, Ph.D., M.P.H., Office of Nutrition Research, NIDDK, NIH
12:15 p.m. – 1:00 p.m.
Poster Session, Lunch, and Exercise Break
Section 3, Part 1: Measuring Potential Contributors to Interindividual Variability in Dietary Responses
Moderator: Elizabeth Parks, Ph.D.
Historically, nutrition research investigating a single nutrient at a time has led to significant advancements in understanding the connection between diet and health. However, the variety of dietary patterns and the complexity of foods necessitate the development of new research strategies to understand real-life responses to food intake and how they differ among individuals. Section 3, Part 1, of the meeting will focus on the contribution of habitual nutritional status as a source of variability in research results. Lifestyle and social factors that influence the individual response to nutrients will be presented, including the effects of the immune system and sleep, health disparities, and psychosocial factors. Section 3, Part 2, will cover the impact of variability in taste and smell, environmental exposures, and ways that the technical measurement of response to eating can influence research findings. The new modeling approaches under development offer much promise in the discovery of how these various factors all fit together to result in a person’s unique dietary response.
1:05 p.m. – 1:20 p.m.
Importance of Examining Nutritional Status as a Source of Interindividual Variability
Marian Neuhouser, Ph.D., RD, Fred Hutchinson Cancer Research Center
1:20 p.m. – 1:35 p.m.
Immune System Status and Inflammatory Responses to Diet
Helen Roche, Ph.D., University College Dublin, School of Public Health
1:35 p.m. – 1:50 p.m.
Sleep and Chronobiology
Frank Scheer, Ph.D., M.Sc., Brigham and Women’s Hospital
1:50 p.m. – 2:05 p.m.
Nutrition-related Health Disparities, Socioeconomic Influences, and Social Determinants of Health
Josiemer Mattei, Ph.D., M.P.H., Harvard T.H. Chan School of Public Health
2:05 p.m. – 2:20 p.m.
Psychosocial and Cultural Factors Influencing Dietary Intake and Patterns
Cheryl Anderson, Ph.D., M.P.H., M.S., University of California, San Diego
2:20 – 2:45 p.m.
Section 3, Part 1 Q&A Live
2:45 p.m. - 3:00 p.m.
Break and Poster Session
Section 3, Part 2: Measuring Potential Contributors to Interindividual Variability in Dietary Responses
3:00 p.m. – 3:15 p.m.
Other Environmental Exposures
Albert-László Barabási, Ph.D., Northeastern University Khoury College of Computer Sciences
3:15 p.m. – 3:30 p.m.
Mixed-meal Challenge Tests, Physiological Measures, and Individual Response to Alcohol
Elizabeth Parks, Ph.D., University of Missouri School of Medicine
3:30 p.m. – 3:45 p.m.
Sensory Nutrition
Valerie Duffy, Ph.D., RD, University of Connecticut
3:45 p.m. – 5:00 p.m.
Section 3, Part 2 Q & A and Panel Discussion: Research Gaps and Opportunities
Saroja Voruganti, Ph.D., The University of North Carolina Gillings School of Global Public Health
Krista Varady, Ph.D., University of Illinois at Chicago
Erin Hanlon, Ph.D., The University of Chicago
Susan Malone, Ph.D., M.S.N., New York University Rory Meyers College of Nursing
5:00 p.m.
Recess
January 12, 2021
_________________________________________________________
9:00 a.m. – 9:10 a.m.
Introduction to Day 2
Bruce Y. Lee, M.D., M.B.A., City University of New York Graduate School of Public Health and Health Policy
Section 4: Training the Next Generation of a Diverse Workforce of Researchers in the Fields of Precision Nutrition and Data Science
Moderator: Bruce Y. Lee, M.D., M.B.A.
9:10 a.m. – 9:15 a.m.
Moderator Introduction
9:15 a.m. – 9:35 a.m.
Strategies to Retain Trainees and Hybrid Fields: NIH Office of Behavioral and Social Sciences Research T32 Training Program
Elizabeth Ginexi, Ph.D., Office of Behavioral and Social Sciences Research, NIH
9:35 a.m. – 9:55 a.m.
Strategies to Retain Trainees and Hybrid Fields
Patricia Mabry, Ph.D., HealthPartners Institute
9:55 a.m. – 10:30 a.m.
Section 4 Q & A and Panel Discussion, Training Recommendations, and Opportunities
Susan Gregurick, Ph.D., Office of Data Science Strategy (ODSS), NIH
Michael Hittle, M.S., Stanford University
Jessica Mazerik, Ph.D., ODSS, NIH
Lorene Nelson, Ph.D., Stanford University
Shurjo Sen, Ph.D., National Human Genome Research Institute
10:30 a.m. – 10:45 a.m.
Break and Poster Sessions
Section 5, Part 1: Systems Science, Data Science, and Computational Analytics
Moderator: Bruce Y. Lee, M.D., M.B.A.
The underlying assumption of precision nutrition is that not everyone responds to diet in the same way. Therefore, one of the goals of precision nutrition is to develop predictive algorithms for what individuals should eat to optimize nutritional status or reduce dis-homeostatic excursions in continuous or repeated physio-metabolic measures (glycemia, blood pressure, heart rate variability, cognition or depression scores, wellness scores, plasma or urine measures, etc.) that serve as or could serve as earlier indicators of health problems or chronic disease biomarkers. The goal would be to use other inputs to develop these predictive algorithms based on various other -omic data (microbiome, genetics, metabolomics, etc.) and non-omic data (actual dietary intake information, physical activity, health disparities, electronic health record, culture, gender, geolocation, sociodemographics, and disparities, etc.).
10:45 a.m. – 11:00 a.m.
Introduction to System Science and Data Analytics
Bruce Lee, M.D., M.B.A.
11:00 a.m. – 11:15 a.m.
Precision Public Health Nutrition: Addressing the Social-ecological Settings in Which People Access and Consume Food
Kayla de la Haye, Ph.D., Keck School of Medicine of the University of Southern California
11:15 a.m. – 11:30 a.m.
Data Analytics and Management: Artificial Intelligence, Such as Machine Learning
Suchi Saria, Ph.D., M.Sc., Johns Hopkins University
11:30 a.m. – 11:45 a.m.
Data Analytics and Management: Artificial Intelligence is More Than AI
Kristian Hammond, Ph.D., Northwestern University McCormick School of Engineering
11:45 a.m. – 12:15 p.m
Section 5, Part 1 Q & A
12:15 p.m. – 1:00 p.m.
Poster Session, Lunch, and Exercise Break
Section 5, Part 2: Systems Science, Data Science, and Computational Analytics
1:00 p.m. – 1:15 p.m.
Interpretation and Translation
Nico Pronk, Ph.D., M.A., HealthPartners Institute
1:15 p.m. – 1:30 p.m.
Ethical Artificial Intelligence
Brendan Parent, J.D., New York University Grossman School of Medicine
1:30 p.m. – 2:45 p.m.
Section 5, Part 2 Q & A and Panel Discussion, Research Gaps and Opportunities, and Case Examples
Eran Segal, Ph.D., Weizmann Institute of Science
Tim Spector, M.D., M.Sc., M.B., FRCP, King’s College London
Abigail Horn, Ph.D., Keck School of Medicine of the University of Southern California
Grace Peng, Ph.D., National Institute of Biomedical Imaging and Bioengineering, NIH
2:45 p.m. – 3:00 p.m.
Break and Poster Session
Section 6: Putting It All Together: What Does the Future Hold for Implementing Precision Nutrition Science?
3:00 p.m. – 4:00 p.m.
Panel Discussion
4:00 p.m. – 4:15 p.m.
Closing Remarks
4:15 p.m.
Adjournment