mouse monoclonal IgG1; PTEN Antibody (A2B1) is an IgG1 κ mouse monoclonal PTEN antibody (also designated phosphatase and tensin homolog antibody) that detects the PTEN protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. PTEN Antibody (A2B1) is available as both the non-conjugated anti-PTEN antibody form, as well as multiple conjugated forms of anti-PTEN antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. Due to the involvment of the PTEN antigen in a broad range of cancers, the PTEN Antibody (A2B1) is an important research tool. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm and shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.