mouse monoclonal IgG2b; Rho D Antibody (H-6) is an IgG2b κ mouse monoclonal Rho D antibody (also designated Rho D antibody) that detects the Rho D protein of human origin by WB, IP, IF, IHC(P) and ELISA. Rho D Antibody (H-6) is available as both the non-conjugated anti-Rho D antibody form, as well as multiple conjugated forms of anti-Rho D antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Upon activation, the small GTPase Rho D (also designated RhoHP1 and ARHD) contributes to rearrangement of the actin cytoskeleton and cell surface and also governs endosome motility and distribution. The effects of Rho D antagonize those of its family member, Rho A, by dissasembling actin stress fibers normally enhanced by Rho A. Additionally, Rho D disengages focal adhesions, resulting in retardation of cell migration. Accordingly, transfection of a constitutively active form of Rho D (designated Rho D G26V) reverses the invasive phenotype of G(α olf) induced cells, implying the possiblity of a therapeutic use for activated Rho D in counteracting tumor metastasis.