mouse monoclonal IgG1; NK-1R Antibody (D-11) is an IgG1 κ mouse monoclonal NK-1R antibody (also designated TACR1 antibody, NK1R antibody, SPR antibody, Substance-P Receptor antibody, NK-1 Receptor antibody, TAC1R antibody, NKIR antibody, or Neurokinin-1 Receptor antibody) that detects the NK-1R protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. NK-1R Antibody (D-11) is available as both the non-conjugated anti-NK-1R antibody form, as well as multiple conjugated forms of anti-NK-1R antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The substance P receptor, also designated NK-1R for neurokinin 1 receptor, is a member of a class of tachykinin receptors which also includes the NK-2 receptor and the NK-3 receptor. Substance P receptors bind to tachykinin peptides, including substance P, substance K and neuromedin K. NK-1R is likely to be involved in nociceptive transmission, basal ganglia function or anxiety and depression. NK-1R is expressed in a high proportion of spinothalmic and spinobranchial neurons located in lamina 1. NK-1R neurons in the dorsal horn of the spinal cord may play a role in chronic neuropathic and inflammatory pain. Ligand-induced internalization of NK-1R into early endosomes deplete the cell surface of these receptors. This internalization may be involved in a down-regulation response of a cell to substance P.