mouse monoclonal IgG1; RIL Antibody (D-8) is an IgG1 κ mouse monoclonal RIL antibody (also designated RIL antibody) that detects the RIL protein of mouse, rat and human origin by WB, IP, IF and ELISA. RIL Antibody (D-8) is available as both the non-conjugated anti-RIL antibody form, as well as multiple conjugated forms of anti-RIL antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. RIL (reversion-induced LIM protein), also known as PDZ and LIM domain protein 4, is a widely expressed 334 amino acid protein. RIL contains one PDZ(DHR) domain and one LIM zinc-binding domain. The LIM zinc-binding domain interacts with the second and fourth PDZ domains of Fap-1, possibly resulting in the dephosphorylization of RIL. Although an exact function is unknown, RIL expression in human bone marrow stromal cells suggests involvement in osteoblast development and function. Variations in the RIL gene have been shown to have an allelic dose effect on bone mineral density (BMD), with BMD being an important determinant of osteoporosis. RIL exists as two isoforms, with isoform 2 present in the brain.