mouse monoclonal IgG2b; SODD Antibody (C-12) is an IgG2b κ mouse monoclonal SODD antibody (also designated SODD antibody) that detects the SODD protein of human origin by WB, IP, IF and ELISA. SODD Antibody (C-12) is available as both the non-conjugated anti-SODD antibody form, as well as multiple conjugated forms of anti-SODD antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The cytokine TNF (tumor necrosis factor) signals through the TNF-R1 receptor to activate various cellular pathways, including apoptosis and NFkB activation. TNF binding induces receptor aggregation, resulting in the recruitment of TRADD, FADD, TRAF2 and RIP to the intracellular "death" domain of the receptor complex, which in turn activates signaling pathways including apoptosis and NFkB activation. SODD, for silencer of death domains, was found to be associated with the intracellular "death" domain of TNF-R1 in the absence of TNF stimulation. TNF treatment results in the release of SODD from TNF-R1, allowing the recruitment of TRADD and TRAF2 to the receptor complex. Thus, SODD may play a role in preventing spontaneous signaling by death-domain receptors, in the absence of ligand.