mouse monoclonal IgG1; β-TrCP/HOS Antibody (F-10) is an IgG1 κ mouse monoclonal beta-TrCP/HOS antibody (also designated beta-transducin repeat containing E3 ubiquitin protein ligase 1/2 antibody, BTRC antibody, BTRC2 antibody, BTRCP1 antibody, BTRCP2 antibody, βTrCP1 antibody, βTrCP2 antibody, F-box/WD repeat-containing protein 1A (FBXW1A) antibody, FBW1A antibody, FBXW1 antibody, FBXW1B antibody, FBXW11 antibody, betaTrCP antibody, ubiquitin protein ligase complex subunit antibody, or phosphorylation-dependent ubiquitin pathway related antibody) that detects the beta-TrCP/HOS protein of mouse, rat and human origin by WB, IP, IF and ELISA. β-TrCP/HOS Antibody (F-10) is available as both the non-conjugated anti-beta-TrCP/HOS antibody form, as well as multiple conjugated forms of anti-beta-TrCP/HOS antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. b-tranducin repeats containing protein (b-TrCP), also designated E3RSIkB or FWD1, and HOS (homologous to Slimb) are F-box proteins that function as substrate recognition subunits of ubiquitin ligases. HOS and b-TrCP differ in their amino-terminal regions, but exhibit high homology within the F-box and WD40 repeat-containing regions. b-TrCP mediates ubiquitin/proteasome-dependent degradation of CD4 and ubiquitination of various proteins including IkB and b-catenin. HOS has also been shown to regulate the degradation of IkB and b-catenin in a similar manner.