mouse monoclonal IgG2b; CacyBP Antibody (H-1) is an IgG2b κ mouse monoclonal CacyBP antibody (also designated CacyBP antibody) that detects the CacyBP protein of mouse, rat and human origin by WB, IP, IF and ELISA. CacyBP Antibody (H-1) is available as both the non-conjugated anti-CacyBP antibody form, as well as multiple conjugated forms of anti-CacyBP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CacyBP (Calcyclin-binding protein, Siah-interacting protein) is a 228 amino acid protein encoded by the human gene CACYBP. CacyBP is primarily a nuclear protein that contains one CS domain and one SGS domain. CacyBP is believed to be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It most likely serves as a molecular bridge in ubiquitin E3 complexes. It also participates in the ubiquitin-mediated degradation of b-catenin. CacyBP is thought to be a potential inhibitor of cell growth and invasion in the gastric cancer cell through its effects on b-catenin protein expression and transcriptional activation of TCF/LEF.