mouse monoclonal IgG2a; NPC2 Antibody (D-3) is an IgG2a κ mouse monoclonal NPC2 antibody (also designated NPC2 antibody) that detects the NPC2 protein of mouse, rat and human origin by WB, IP, IF and ELISA. NPC2 Antibody (D-3) is available as both the non-conjugated anti-NPC2 antibody form, as well as multiple conjugated forms of anti-NPC2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Niemann-Pick disease, type C2 (NPC2), also known as epididymal secretory protein, is a secreted protein mapping against gene 14q24.3. NPC2 regulates the lipid composition of sperm membranes during maturation in the epididymis(1,2). Mutations in the NPC2 gene may cause Nieman-Pick type C2 disease and frontal lobe atrophy (1,2,3). Nieman-Pick type C2 is a fatal hereditary disease characterized by defective lysosome release of cholesterol. The disease is caused by HE1 deficiency, a lysosmal protein proven to be undetectable in fibroblasts from NPC2 patients. This differentiates NPC2 from NPC1, as NPC1 has HE1 protein present.