Proteins possess diverse conformations, some pivotal in disease pathology. Protein misfolding and aggregation are linked to neurodegenerative conditions like Alzheimer's, Parkinson’s, and Huntington’s disease, and non-neurological ailments such as cataracts, certain atherosclerosis forms, short-chain amyloidosis, and cancer. A better understanding of the toxic effects and clearance of misfolded proteins may reveal novel strategies for the prevention and treatment of many diseases.
Combining Next-Generation Protein Sequencing™ with protein barcoding enables high-throughput mapping of non-native conformations, unattainable through crystallization, connecting them to phenotypic effects—an arduous task with conventional methods.
Download the case study “Use of Protein Barcodes and Next-Generation Protein Sequencing™ for High-Throughput Mapping of Protein Conformations and Their Phenotypic Effects” to explore how protein barcoding enhances the understanding of the toxic effects and clearance of misfolded proteins, aiding in the comprehension of disease mechanisms.