mouse monoclonal IgG2b; NF45 Antibody (H-4) is an IgG2b κ mouse monoclonal NF45 antibody (also designated NF45 antibody) that detects the NF45 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. NF45 Antibody (H-4) is available as both the non-conjugated anti-NF45 antibody form, as well as multiple conjugated forms of anti-NF45 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. NF45 (ILF2, nuclear factor of activated T cells 45 kDa) is a transcription factor that interacts with NF90 (ILF3, DRBP76) to regulate gene expression. NF45 and NF90 are proteins that belong to the double-stranded RNA-binding protein family and both are substrates for the dsRNA-activated protein kinase, PKR. The NF45/NF90 heterodimer is mainly involved in regulating IL-2 expression by binding to the antigen receptor response element (ARRE) target sequence of the IL-2 enhancer. In neuronal cells, the NF45/NF90 heterodimer can repress human rhinovirus type 2 replication by binding to a 5' untranslated region of the viral RNA that encodes the internal ribosome entry site (IRES).