mouse monoclonal IgG1; VAC14 Antibody (F-12) is an IgG1 κ mouse monoclonal VAC14 antibody that detects VAC14 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. VAC14 Antibody (F-12) is available as the non-conjugated anti-VAC14 antibody form, as well as multiple conjugated forms of anti-VAC14 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a signaling molecule that exists as a minor component of cell membranes and is essential for the distinguishing of cellular compartments. The synthesis of PI(3,5)P2 is regulated by a number of proteins that are involved in intracellular trafficking and assembly events throughout the cell. VAC14, also known as TAX1BP2 (Tax1-binding protein 2) or TRX, is a 782 amino acid protein that contains six HEAT repeats and exists as part of a regulatory complex with FIG4. Expressed ubiquitously, VAC14 works with FIG4 to control the synthesis of PI(3,5)P2, specifically mediating the activation of PIP5KIII, a kinase involved in the regulation of PI(3,5)P2 activity. The gene encoding VAC14 maps to human chromosome 16, which houses over 900 genes and comprises nearly 3% of the human genome.