mouse monoclonal IgG2b; FBL10 Antibody (5G1) is an IgG2b κ mouse monoclonal FBL10 antibody (also designated FBL10 antibody) that detects the FBL10 protein of human origin by WB, IP, IF, IHC(P) and ELISA. FBL10 Antibody (5G1) is available as the non-conjugated anti-FBL10 antibody. FBXL10 (F-box and leucine-rich repeat protein 10), also known as Fbl10, CXXC2 (CXXC-type zinc finger protein 2), PCCX2, KDM2B, JEMMA (jumonji domain, EMSY-interactor, methyltransferase motif protein) or JHDM1B (jumonji C domain-containing histone demethylase 1B), is a nuclear protein that contains one F-box domain, a CXXC-type zinc finger, one JMJC domain, four leucine-rich repeats and one PHD-type zinc finger. FBXL10 belongs to the Fbls class of F-box proteins that contain leucine-rich repeats in addition to their F-box motif. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. In addition to its role in substrate recognition as a component of the E3 complex, FBXL10 functions as a dimethylation-specific demethylase, binding iron as a cofactor and demethylating lysine-36 of Histone H3. This suggests that FBXL10 plays a central role in the histone code.